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This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results. It gathers patient data from hospital and Mediston systems, with main focus on in-hospital complications and secondary focus on ICU stay, post-op hospitalization, mortality, and intubation time. The research aims to deepen understanding of anesthetic management's role in lung transplant outcomes and guide improvements in perioperative anesthesia protocols.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lung transplantation group | In this group, we collected perioperative clinical data and analyzed risk factors associated with patient outcomes. |
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| Measure | Description | Time Frame |
|---|---|---|
| In-hospital adverse events | In-hospital adverse events were defined as post-transplant complications occurring prior to discharge, such as: Grade 3 PGD, respiratory infections, stroke, cardiac events, AKI, or liver impairment. | Collect data for an expected average about 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| ICU stay | The ICU stay （days） was calculated from the time of ICU admission after surgery completion to actual discharge from the intensive care unit | Collect data for an expected average about 2 hours |
| Postoperative hospital stay |
| Measure | Description | Time Frame |
|---|---|---|
| Grade 3 Primary Graft Dysfunction (PGD) | PGD3:A ratio of arterial oxygen partial pressure to fraction of inspired oxygen (PaO₂/FiO₂) < 200 mmHg with bilateral infiltrates on chest radiograph, or Requirement for extracorporeal life support (ECLS) within 72 hours postoperatively, or use of inhaled pulmonary vasodilators for >48 hours during mechanical ventilation. | Collect data for an expected average about 2 hours |
Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University between January 2017 and October 2024
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Diansan Su, Dr | Contact | +8618616514088 | diansansu@yahoo.com | |
| chaoqin Chen, Dr | Contact | +8613567148312 | chenchaoqin09@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000 | Hangzhou | Zhejiang | 310000 | China |
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Postoperative hospital（days）stay after lung transplantation
| Collect data for an expected average about 2 hours |
| In-hospital mortality | The proportion of patients who died during the initial hospitalization period following lung transplantation surgery | Collect data for an expected average about 2 hours |
| 30-day postoperative mortality | Number of deaths within 30 days post-transplant) / (Total number of lung transplant recipients) × 100%； | Collect data for an expected average about 2 hours |
| 90-day postoperative mortality | Number of deaths within 90 days post-transplant) / (Total number of lung transplant recipients) × 100% | Collect data for an expected average about 2 hours |
| The duration of endotracheal intubation | Duration of intubation should be recorded from surgery end-time to extubation | Collect data for an expected average about 2 hours |
| Pulmonary Infection | Radiologically confirmed by a staff radiologist as new or progressive pulmonary infiltrates on: Chest X-ray or Computed tomography (CT) scan | Collect data for an expected average about 2 hours |
| Acute Kidney Injury | A rise in serum creatinine >120 μmol/L | Collect data for an expected average about 2 hours |
| Cardiovascular Events | Acute myocardial infarction； heart failure；Cardiovascular hemorrhage；Clinically significant arrhythmias；Conduction system disorders；Cardiac arrest；Refractory hypotension due to cardiogenic sock. | Collect data for an expected average about 2 hours |
| Hepatic Dysfunction | Aspartate aminotransferase (AST) >34 or Alanine aminotransferase (ALT) >40 U/L; | Collect data for an expected average about 2 hours |
| Cerebral Infarction | Diagnosed by staff radiologists as new or progressive ischemic lesions on CT or MRI | Collect data for an expected average about 2 hours |
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D017563 | Lung Diseases, Interstitial |
| D001987 | Bronchiectasis |
| D012131 | Respiratory Insufficiency |
| D054990 | Idiopathic Pulmonary Fibrosis |
| D012829 | Silicosis |
| D014397 | Tuberculosis, Pulmonary |
| D006976 | Hypertension, Pulmonary |
| D011660 | Pulmonary Heart Disease |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001982 | Bronchial Diseases |
| D012120 | Respiration Disorders |
| D011658 | Pulmonary Fibrosis |
| D011009 | Pneumoconiosis |
| D055370 | Lung Injury |
| D009784 | Occupational Diseases |
| D014376 | Tuberculosis |
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D012141 | Respiratory Tract Infections |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
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