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| ID | Type | Description | Link |
|---|---|---|---|
| IDRCB : 2023-A02724-41 | Other Identifier | ANSM |
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Carcinological oesophageal resection surgery is one of the so-called major digestive surgeries, i.e. involving a high perioperative risk (morbidity and mortality) in patients who are malnourished or at high risk of malnutrition.
Nutritional therapy for these patients is an important part of overall perioperative management. Lewis-Santy oesophageal surgery requires a thoracic approach (thoracotomy or thoracoscopy) and an abdominal approach (laparotomy or laparoscopy).
Resumption of oral feeding is contraindicated in the immediate postoperative period. The use of a feeding jejunostomy is not systematic. The methods used to manage artificial nutritional support vary between centres, but the foreseeable duration of fasting and/or intake of less than 50% of nutritional requirements is always greater than 5 days.
At present, total energy requirements are calculated using formulae that take into account the patient's inflammatory state (stable, unstable or stabilised patient), theoretical ideal weight and previous nutritional status, in order to come as close as possible to actual energy expenditure, and are the subject of perioperative nutrition protocols specific to each centre. Indirect calorimetry makes it possible to reliably measure energy expenditure during the perioperative period.
The OESOCAL study continues this line of reasoning. It assumes that energy expenditure may vary according to the surgical approach, and that indirect calorimetry can be used to optimise nutritional support in order to avoid over- or under-nutrition, which may be responsible for an increase in infectious complications.
The results of this study should enable current nutrition protocols to evolve and nutritional support to be incorporated into a more global project of individualised perioperative medicine.
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| Measure | Description | Time Frame |
|---|---|---|
| Determining perioperative dynamics of energy expenditure | Describe the perioperative dynamics of energy expenditure in patients undergoing Lewis-Santy carcinological oesophagectomy as a function of surgical technique by indirect calorimetry (assessing resting energy expenditure ). | Perioperative resting energy expenditure: preoperatively on Day-21/Day-15 or Day-1 of the operation and postoperatively on Day2-Day4 and Day6-Day8 |
| Measure | Description | Time Frame |
|---|---|---|
| Total nutritional intake (vitamin intake) | Assessing patients' total nutritional intake in the perioperative period | pre-operatively on Day-21/Day-15 or Day-1 of the operation and post-operatively on Day2-Day4 |
| Total nutritional intake (parenteral/enteral nutrition) |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive adult patient admitted for digestive surgery for Lewis Santy oesophagectomy
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David DM MALLET, Director | Contact | 2 32 88 82 65 | +33 | Secretariat.DRC@chu-rouen.fr |
| Vincent VF FERRANTI, Arc | Contact | 2 32 88 82 65 | +33 | vincent.ferranti@chu-rouen.fr |
| Name | Affiliation | Role |
|---|---|---|
| Emilie EO OCCHIALI, Doctor | Surgical Intensive Care Unit, UH of Rouen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service d'Anesthésie-Réanimation | Not yet recruiting | Amiens | 80054 | France |
The data provided will be the property of the sponsor and will be used solely for its own research activities.
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Post-operative nutritional support: parenteral/enteral nutrition intake |
| pre-operatively on Day-21/Day-15 or Day-1 of the operation and post-operatively on Day2-Day4 |
| Total nutritional intake (Trace elements) | Post-operative nutritional support: trace elements intake | pre-operatively on Day-21/Day-15 or Day-1 of the operation and post-operatively on Day2-Day4 |
| Comparison of calorie targets set with data measured by indirect calorimetry | Comparison of calorie targets set by the postoperative artificial nutrition protocol with data measured by indirect calorimetry | Perioperative resting energy expenditure: preoperatively on Day-21/Day-15 or Day-1 of the operation and postoperatively on Day2-Day4 and Day6-Day8 |
| Post-operative complications | Postoperative morbidity and mortality, surgical complications evaluation | at 6 and 12 months |
| Department of Anaesthesia and Intensive Care | Not yet recruiting | Brest | 29200 | France |
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| Surgical Intensive Care Department | Recruiting | Rouen | 76031 | France |
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| Department of Anaesthesia, Intensive Care and Perioperative Medicine | Not yet recruiting | Vandœuvre-lès-Nancy | 54511 | France |
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