HLA Antibodies in Systemic Lupus Erythematosus

HLA Antibodies in Systemic Lupus Erythematosus

Patients suffering from autoimmune diseases show false-positive results when anti-HLA antibodies are identified. This false positivity makes it difficult to obtain an organ transplant based on immunological compatibility (absence of anti-HLA antibodies directed against graft antigens). The objectives of this project are to study the prevalence of these false positivities in a population of lupus patients, and to evaluate biological tests that can negate these false positivities.

Inclusion Criteria:

• Patients Adults
• Followed in the internal medicine department of Amiens University Hospital - With systemic lupus erythematosus
• Without HLA immunization risk factors (no history of pregnancy, transfusions or transplants)
• With sera stored in the biobank

Exclusion Criteria:

• minor Patients
• Opposing the re-use of their personal data for research purposes