PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network

PRevention Of Trauma-related Infections Through an Embedded Clinical Trials (PROTECT) Network

The purpose of this study is to compare the effectiveness of 2 prophylactic antibiotic regimens, ertapenem and cefazolin with metronidazole, in preventing organ space surgical site infections (OS-SSI) after emergency trauma laparotomy embedded into routine clinical care and to validate a Bayesian OS-SSI risk calculator using Trauma Quality Improvement Program (TQIP) standardized variables

Inclusion Criteria:

• Trauma laparotomy within 90 minutes of arrival

Exclusion Criteria:

• Patients with a known allergy to cephalosporins or β-lactamase inhibitors
• Prisoners
• Pregnant and lactating women