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Primary immune thrombocytopenia (PIT), previously referred to as idiopathic thrombocytopenic purpura, is an acquired disease characterized by accelerated platelet destruction and deficient platelet production by megakaryocytes.
Although the existence of PIT has been known for decades, there is no consensus on its triggering mechanisms. On the other hand, this disease presents a very heterogeneous patient profile, both in its characteristics and treatments. In this sense, the diagnosis is still made by excluding other causes of thrombocytopenia.
There is insufficient epidemiological data on the disease, a fact that is especially evident in our country. We have no data on the incidence or prevalence of this pathology in Spain.
For all these reasons, this epidemiological study has been designed to increase the available knowledge about this disease and the detailed characterization of the population of patients with ITP in Spain.
The main objective of this study is to describe the clinical, analytical and treatment characteristics of primary immune thrombocytopenia and other immune thrombocytopenia.
The study is an epidemiological, ambispective, multicenter study carried out in hospitals in Spain.
Information will be collected on the disease under study, as well as on the treatments received, using the patient's clinical history as a source document.
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| Measure | Description | Time Frame |
|---|---|---|
| Description of the clinical and analytical features of PIT and other immune thrombocytopenias. | From enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison with published historical ITP data | From enrollment | |
| Definition of therapeutic strategies and most common treatments in ITP | From enrollment | |
| Evaluation of response to first-line treatment |
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Inclusion Criteria:
Exclusion Criteria:
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People with the diagnostic presumption of PIT or other thrombocytopenia of probable immune origin defined as a platelet count < 100 x 109/L.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cristina Pascual Izquierdo, MD | Contact | 91 586 8445 | sehh@sehh.es | |
| Amanda López Picado | Contact | 646075853 | sehh@sehh.es |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Complexo Hospitalario Universitario A Coruña | Recruiting | A Coruña | A Coruña | 15006 | Spain |
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| From enrollment |
| Evaluation of response to subsequent treatments | From enrollment |
| Hospital Universitario Son Espases | Recruiting | Palma | Balearic Islands | 07120 | Spain |
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| Hospital Del Mar | Recruiting | Barcelona | Barcelona | 08003 | Spain |
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| Hospital Vall d'Hebron ( | Not yet recruiting | Barcelona | Barcelona | 08035 | Spain |
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| Hospital Universitario Mutua Terrassa | Not yet recruiting | Terrassa | Barcelona | 08221 | Spain |
|
| Hospital de Basurto | Recruiting | Bilbao | Biskaia | 48013 | Spain |
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| Hospital Sierrallana | Not yet recruiting | Torrelavega | Cantabria | 39300 | Spain |
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| Hospital de La Plana | Recruiting | Castellon | Castellón | 12540 | Spain |
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| Hospital Universitario Punta de Europa | Recruiting | Algeciras | Cádiz | 11207 | Spain |
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| Hospital Puerta del Mar | Recruiting | Cadiz | Cádiz | 11009 | Spain |
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| Hospital Universitario de Jerez | Recruiting | Jerez de la Frontera | Cádiz | 11407 | Spain |
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| Hospital Universitario Reina Sofia de Córdoba | Recruiting | Córdoba | Córdoba | 14004 | Spain |
|
| Hospital Universitario Virgen de las Nieves | Recruiting | Granada | Granada | 18014 | Spain |
|
| Hospital Juan Ramón Jimenez | Recruiting | Huelva | Huelva | 21005 | Spain |
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| Complejo Hospitalario de Jaén | Recruiting | Jaén | Jaén | 23007 | Spain |
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| Hospital Universitario Lucus Augusti | Recruiting | Lugo | Lugo | 27003 | Spain |
|
| Hospital Universitario Arnau de Vilanova | Not yet recruiting | Lleida | Lérida | 25198 | Spain |
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| Hospital Infantil Universitario Niño Jesús | Recruiting | Madrid | Madrid | 28009 | Spain |
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| Hospital Clínico San Carlos | Recruiting | Madrid | Madrid | 28040 | Spain |
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| Hospital General Universitario Gregorio Marañón | Recruiting | Madrid | Madrid | 28040 | Spain |
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| Hospital Universitario 12 octubre | Recruiting | Madrid | Madrid | 28041 | Spain |
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| Hospital Universitario La Paz | Not yet recruiting | Madrid | Madrid | 28046 | Spain |
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| Hospital Universitario Costa del Sol | Recruiting | Marbella | Málaga | 29603 | Spain |
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| Hospital Universitario Regional de Málaga | Recruiting | Málaga | Málaga | 29010 | Spain |
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| Hospital Universitario Virgen de la Victoria | Recruiting | Málaga | Málaga | 29010 | Spain |
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| Hospital materno infantil de Málaga | Recruiting | Málaga | Málaga | 29011 | Spain |
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| Hospital de la Serranía de Ronda | Recruiting | Ronda | Málaga | 29400 | Spain |
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| Hospital Universitario de Navarra | Recruiting | Pamplona | Navarre | 31008 | Spain |
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| Hospital Universitario Central de Asturias | Recruiting | Oviedo | Principality of Asturias | 33011 | Spain |
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| Complejo Asistencial Universitario de Salamanca | Not yet recruiting | Salamanca | Salamanca | 37007 | Spain |
|
| Hospital Universitario de Canarias | Recruiting | Santa Cruz de Tenerife | Santa Cruz de Tenerife | 38320 | Spain |
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| Hospital de la Merced | Not yet recruiting | Osuna | Sevilla | 41640 | Spain |
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| Hospital Universitario Virgen de la Macarena | Recruiting | Seville | Sevilla | 41009 | Spain |
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| Hospital Universitario Virgen del Rocio | Recruiting | Seville | Sevilla | 41013 | Spain |
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| Hospital Clínico de Valencia | Recruiting | Valencia | Valencia | 46010 | Spain |
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| Hospital Universitario Miguel Servet | Recruiting | Zaragoza | Zaragoza | 50009 | Spain |
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| ID | Term |
|---|---|
| D016553 | Purpura, Thrombocytopenic, Idiopathic |
| ID | Term |
|---|---|
| D011696 | Purpura, Thrombocytopenic |
| D011693 | Purpura |
| D001778 | Blood Coagulation Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D057049 | Thrombotic Microangiopathies |
| D013921 | Thrombocytopenia |
| D001791 | Blood Platelet Disorders |
| D000095542 | Cytopenia |
| D006474 | Hemorrhagic Disorders |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |
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