Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria

Colonic Capsule Endoscopy for Screening of Neoplasms in Patients With Anaerobic Bacteremia

The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria. The main question it aims to answer is:

• How prevalent is cancer and precancerous tumors in the large intestines and rectum in patients with anaerobic bacteremia? Participants will be offered an examination using colon capsule endoscopy 4-8 weeks after discharge.

Inclusion Criteria:

• Older than 18 years
• Blood culture with growth of one or more of the following bacterial genera Bacteroides, Clostridium, Filifactor, Fusobacterium, Gemella, Granulicatella, Parvimonas, Peptostreptococcus, Prevotella, Solobacterium, Peptoniphilus, Ruminococcus, Finegoldia and Streptococcus.
• Able to provide oral and written informed consent
• Able to read and speak Danish

Exclusion Criteria:

• Prior colorectal cancer diagnosis
• History of stenosis of the gastrointestinal tract
• Previous treatment of inflammatory bowel disease
• Previous major surgery of the gastrointesinal tract (e.g. gastric bypass)
• Colostomy
• Pacemaker/ICD
• Pregnancy or breastfeeding
• Allergies to the bowel preparation regimen
• Severe kidney disease
• Focus of infection in skin and soft tissue or outside the truncus (e.g. decubitus, diabetic foot ulcer)
• Tumor in the colon or rectum at diagnostic imaging
• Transfer to other hospital outside the region