Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 32471114 | Other Grant/Funding Number | The National Natural Science Foundation of China grant |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Nanyang Technological University | OTHER |
Not provided
Not provided
Not provided
Drug addiction persists as a significant global social concern with a negative impact on social harmony and stability that cannot be ignored. After returning to society, individuals with drug addiction often suffer from impaired creative problem-solving abilities and difficulties in interpersonal cooperation. The difficulties in survival stress and the sense of helplessness triggered by these factors are important reasons that lead them to seek drugs repeatedly and even to commit criminal behaviors. Therefore, enhancing creative realistic problem-solving abilities emerges as a pivotal pathway for drug addicts to facilitate rehabilitation from drug addiction and achieve societal adaptation. The project emphasizes both individual and collaborative creative solution generation for realistic problem solving. The abnormal cognitive neural mechanisms and interpersonal neural mechanisms will be systematically explored by using multiple cognitive and neuroimaging methods, such as functional near-infrared spectroscopy (fNIRS), electroencephalography (EEG), and eye-tracking. From the cognitive-behavioral-brain level, a comprehensive neurophysiological multimodal predictive model of how drug addiction affects creative realistic problem-solving will be constructed by multi-level data fitting modeling. Building upon this research foundation, The investigators will further implement single and repeated sessions of transcranial direct current stimulation (tDCS) targeting damaged brain regions for the intervention of individual and collaborative problem-solving ability under the effect of drug addiction. The indicators of brain, cognition, and behavior will be tracked at multiple time points.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active group | Active Comparator | The study was sham-controlled, randomized, and double-blind. Participants with HUD were randomly assigned to either the active or sham groups. The DC-STIMULATOR PLUS (neuroConn, Germany) was used to deliver stimulation via saline-soaked sponge electrodes (25 cm², 5×5 cm, 1.5 mA). The stimulation in the active group lasted for 20 min with a 30-s fade-in and a 30-s fade-out. They received five stimulation sessions within one week, with a minimum interval of 24 hours between each session. The tDCS sensitivity questionnaire was used to assess blinding validity. |
|
| Sham group | Sham Comparator | Arm Description: The study was sham-controlled, randomized, and double-blind. Participants with HUD were randomly assigned to either the active or sham groups. The DC-STIMULATOR PLUS (neuroConn, Germany) was used to deliver stimulation via saline-soaked sponge electrodes (25 cm², 5×5 cm, 1.5 mA). The stimulation in the sham group was set up as a stimulation cycle of 30s fade-in and 30s fade-out, followed by no current stimulation. They received five stimulation sessions within one week, with a minimum interval of 24 hours between each session. The tDCS sensitivity questionnaire was used to assess blinding validity. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial direct current stimulation | Device | The participant cohort recruited for this study consists of individuals with drug addiction specifically those addicted to drugs. During the intervention phase, this group will adhere to a strict non-pharmacological intervention protocol, meaning they will not receive any form of pharmacotherapy, neurosurgical intervention, or other neuromodulation-based cognitive interventions, including but not limited to techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). This design aims to ensure the internal validity of the study results and to exclude potential confounding effects of other interventions on neuroplasticity and cognitive function. |
| Measure | Description | Time Frame |
|---|---|---|
| Score on the Realistic Presented Problem Task | Used to measure problem-solving ability individual creative problem-solving | From enrollment to the end of treatment at 1 month |
| Score on the Group Realistic Problem Solving Task | Used to measure collaborative problem-solving ability | From enrollment to the end of treatment at 1 month |
| Cortical activation from fNIRS | From enrollment to the end of treatment at 1 month | |
| Cortical functional connectivity from fNIRS | From enrollment to the end of treatment at 1 month | |
| Inter-brain neural synchronization from fNIRS hyperscaning | From enrollment to the end of treatment at 1 month | |
| Pupil response from eye-tracking | From enrollment to the end of treatment at 1 month | |
| Score on the Alternative Use Task | Used to measure the individual problem-solving ability | From enrollment to the end of treatment at 1 month |
| Score on the Group Alternative Use Task | Used to measure collaborative problem-solving | From enrollment to the end of treatment at 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Average fixation duration from eye-traking | From enrollment to the end of treatment at 1 month | |
| Fixation time percentage from eye-traking | From enrollment to the end of treatment at 1 month | |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shaanxi Provincial Chang'an Compulsory Isolation Drug Rehabilitation Center | Xi'an | Shaanxi | 710062 | China |
This study is a government-collaborative project involving sensitive personal information of a vulnerable population, and as such, it is imperative to adhere to strict confidentiality protocols. All data collected will be handled in compliance with ethical guidelines and legal requirements to ensure the protection of participants' privacy.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Score on the joint drawing task |
Used to measure collaborative problem-solving from the perspective of social interaction. |
| From enrollment to the end of treatment at 1 month |
| Score on the Chain Free Association Task | Used to measure remote associative ability. | From enrollment to the end of treatment at 1 month |
| Score on the Verbal Fluency Task | Used to measure remote association ability | From enrollment to the end of treatment at 1 month |
| Score on the Divergent Association Task | used to measure the divergent Association ability | From enrollment to the end of treatment at 1 month |
| Score on the Wsiconsin Card Sorting Test (WCST) | Used to measure cognitive flexibility. | From enrollment to the end of treatment at 1 month |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |