The goal of this clinical trial is to understand if Resomelagon can treat adult patients with Dengue virus infection. The main questions the investigators aim to answer are:

Is Resomelagon safe to use in patients with Dengue? Is Resomelagon able to reduce the duration of illness? (defined by clinical and laboratory criteria) Participants will be allocated to Resomelagon or placebo groups in this study and asked to take the medication and submitted to blood tests.

Inclusion Criteria:

• Patients who are 18 to 65 years old;
• Able to understand study procedures and give informed consent;
• Presents with more than 36 and less than 84h since symptoms onset;
• Symptoms compatible with dengue infection (fever, myalgia, arthralgia, headache or conjunctivitis) with positive antigen test or polymerase chain reaction test.

Exclusion Criteria:

• Has any comorbidity which is perceived as significant by the investigator;
• Significant laboratory abnormalities discovered at triage: Hemoglobin <10g/dL; Platelet count < 50.000/microL; alanine transaminase > 3x upper limit of normal; Total bilirubin >1,5 x upper limit of normal; glomerular filtration rate < 60mls/min/1,73m2;
• Contraindications or known hypersensitivity to Resomelagon;
• Presents as dengue with warning signs or severe dengue at inclusion;
• Currently participating in another drug clinical trial;
• Clinical evidence of another infection that might explain current symptoms;
• Pregnant women or women actively trying to achieve pregnancy.