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Using a longitudinal cohort design, we will compare the impact of a high BA-binding blenderized diet compared to a low BA-binding blenderized diet and an amino acid-based formula, on gastrointestinal and pulmonary hospitalization and emergency room visit rates over six months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| amino acid-based formula |
| ||
| Low bile binding blenderized diet |
| ||
| High bile binding blenderized diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| amino acid formula | Drug | amino acid formula for 6 months |
| |
| Measure | Description | Time Frame |
|---|---|---|
| total hospitalization and emergency room visits rates | total hospitalization and emergency room visits rates between participants receiving H-BBB and those receiving L-BBB or an amino acid-based formula | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| differences in pulmonary, gastrointestinal or ICU admission rates | differences in pulmonary, gastrointestinal or ICU admission rates between diets | 6 months |
| differences in bile acid concentrations |
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Inclusion Criteria:
Exclusion Criteria:
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Children requiring gastrostomy tube feeds for feeding difficulties
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| low bile acid binding blenderized diet |
| Drug |
low bile acid binding blenderized diet for 6 months |
|
| high bile acid binding blenderized diet | Drug | high bile acid binding blenderized diet for 6 months |
|
differences in bile acid concentrations between diets
| 6 months |
| correlations between microbial abundance and diversity and hospitalization and emergency room visit rates | correlations between microbial abundance and diversity and hospitalization and emergency room visit rates | 6 months |
| differences in metagenomic patterns between diets | 6 months |
| correlations between admission rates by diet type and short chain fatty acid concentrations | 6 months |