Hypoxia, Appetite, and Energy Intake in Young Female Adults

Appetite and Energy Intake in Young Female Adults During and After Simulated High-Altitude

The goal of this clinical trial is to investigate the effects of acute passive continuous hypoxemia (simulated high-altitude at rest) on appetite and energy intake in healthy young female adults. The main questions it aims to answer are:

• Does six hours of simulated high-altitude (5000 meters) reduce scores of subjective appetite and energy intake?
• Do changes in appetite and energy intake persist in the hours following the end of hypoxic exposure? Researchers will compare the effects of simulated high-altitude to a control normoxia (sea-level) condition to see if exposure to low oxygen levels independently affect appetite and energy intake.

Participants will:

• Visit the laboratory for a preliminary screening session to assess eligibility.
• Undergo two randomized, single-blind, experimental sessions consisting of six hours of passive exposure to normoxia or hypoxia in a climate-controlled chamber.
• Consume foods provided from a curated list, served in ad libitum quantities, after leaving the laboratory to assess post-exposure energy intake.

Inclusion Criteria:

• English or French speaking
• Ability to provide informed consent

Exclusion Criteria:

• History or evidence of chronic disease
• Current use of hypolipemic medication
• Current use of hormonal contraceptives
• Current use of antidepressants
• Current use of anticoagulants
• Ongoing smoking status
• Experiencing pregnancy, puerperium, or irregular menstrual cycles