Comparison of Sevoflurane and Propofol on ANI

Comparison of Sevoflurane and Propofol on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study

The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.

Patients will be allocated to either propofol or sevoflurane group. Nociceptive event will be defined as long-lasting tetanic stimulation, square-wave, duration of 30 seconds , amplitude of 50mA, frequency of 50 Hz. analgesia nociception index value and hemodynamic parameters will be recorded 1-minute before and after nociceptive event.

Inclusion Criteria:

• American society of anesthesiologists physical status class I or II

Exclusion Criteria:

• history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc.
• history of allergic reaction to sevoflurane and/or propofol
• history of and/or family history of malignant hyperthermia
• neurodegenerative disorder
• psychiatric disorder
• arrhythmia
• diabetes mellitus
• drug abuse history