Background: Hematopoietic stem cell transplantation (HSCT) is a highly aggressive treatment, which is associated with numerous treatment-related side effects, such as fatigue and decreased functional activity. While recent studies have shown that physical exercise for patients undergoing HSCT is safe and feasible, and has a positive effect on the quality of life, fatigue, and lower limb muscle strength. However, there is no consensus regarding the intensity, type and frequency of exercise program, and few studies mention the patients' experience of exercise barriers and facilitators during HSCT. Therefore, the clinical implementation of exercise program is quite difficult.

Purpose: The purpose of this study is to develop a feasible exercise program for hospitalized patients undergoing hematopoietic stem cell transplantation.

Methods: Action Research is used to collect quantitative and qualitative data. Through the rolling revision of the exercise program during HSCT, finally develop a feasible exercise program.

Expected results: Developing a feasible exercise program for hospitalized patients undergoing hematopoietic stem cell transplantation.

Inclusion Criteria:

1. First-time hematopoietic stem cell transplantation (HSCT) patients who are ambulatory, their primary caregivers, and physical therapists and nurses participating in the exercise intervention;
2. Age 20 years or older;
3. Capable of understanding and complying with the study objectives;
4. No psychiatric disorders or cognitive impairments.

Exclusion Criteria:

1. HSCT patients deemed unsuitable for exercise participation based on the attending physician's assessment;
2. HSCT patients at risk of fractures or confined to bed rest due to musculoskeletal conditions.

First-time hematopoietic stem cell transplantation (HSCT) patients and their primary caregivers, and physical therapists and nurses at Chimei Medical Center.

Individual participant data (IPD) will not be shared due to the following reasons:

1. Privacy and confidentiality concerns - The study involves sensitive medical information from HSCT patients and personal experiences from healthcare providers.
2. Ethical restrictions - The informed consent obtained from participants did not include permission for data sharing beyond the research team.
3. Hospital policy compliance - The participating medical center's regulations restrict the sharing of patient-related data to protect patient privacy.
4. Small sample size - With only 24 participants, sharing individual data might risk participant identification, even if anonymized.