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| Name | Class |
|---|---|
| The Second People's Hospital of Anhui Province | OTHER |
| The First People's Hospital of Hefei | OTHER |
| Qilu Hospital of Shandong University | OTHER |
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This randomized, prospective, parallel, single-blind, multicenter clinical trial investigates the efficacy and safety of intracardiac echocardiography (ICE)-guided catheter ablation versus pressure-sensing catheter ablation alone in reducing PVC recurrence among patients with confirmed papillary muscle-originating premature ventricular contractions (PVCs). Participants were randomly allocated to either the ICE-guided intervention group or the conventional ablation control group following definitive diagnosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intracardiac echocardiography (ICE)-guided catheter ablation | Experimental | Intracardiac echocardiography (ICE)-guided catheter ablation. |
|
| Pressure-sensing catheter ablation alone | Active Comparator | Pressure-sensing catheter ablation alone. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intracardiac echocardiography (ICE)-guided catheter ablation | Procedure | Intracardiac echocardiography (ICE)-guided catheter ablation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Freedom from VC recurrence | Freedom from VC recurrence (defined as a ≥80% reduction in VC burden, calculated as [number of VCs per 24 hours / total number of heartbeats per 24 hours] × 100%). | Patients were followed up at 3 months postoperatively to assess recurrence. |
| Measure | Description | Time Frame |
|---|---|---|
| VC burden reduction | Preoperative VC burden [%] - postoperative VC burden [%]. | Patients were followed up at 3 months postoperatively to assess recurrence. |
| Total procedure time | Total procedure time. |
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Inclusion Criteria:
Exclusion Criteria:
AST/ALT >3× upper limit of normal (ULN); Serum creatinine (SCr) >3.5 mg/dl or creatinine clearance (Ccr) <30 ml/min.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Chest Hospital | Shanghai | Xuhui | 200030 | China |
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| Fujian Medical University Union Hospital |
| OTHER |
| Chinese Academy of Medical Sciences, Fuwai Hospital | OTHER |
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| Pressure-sensing catheter ablation alone | Procedure | Pressure-sensing catheter ablation alone |
|
| From the start to the end of the procedure. |
| Total fluoroscopy time | Total fluoroscopy time. | From the start to the end of the procedure. |
| Major perioperative complications | Including cardiac tamponade, atrioventricular block, stroke, or pulmonary embolism. | 30 days postoperatively. |
| ID | Term |
|---|---|
| D018879 | Ventricular Premature Complexes |
| ID | Term |
|---|---|
| D005117 | Cardiac Complexes, Premature |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000075224 | Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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