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For seniors aged 65 and over (inclusive) undergoing surgical procedures (bone surgery, traumatology, orthopedics) in an acute or elective setting, the relationship between preoperative urinary tract infection/colonization (within 30 days before the procedure) and the occurrence of predefined postoperative complications (monitoring during the patients' hospitalization) will be observed
For seniors aged 65 and over (inclusive) undergoing surgical procedures (bone surgery, traumatology, orthopedics) in an acute or elective setting, the relationship between preoperative urinary tract infection/colonization (within 30 days before the procedure) and the occurrence of predefined postoperative complications (monitoring during the patients' hospitalization) will be observed Among the monitored parameters before the surgical procedure will be urine collection (chemical + sediment - a common part of the pre-anesthetic examination), and in case of findings, a sample for bacteriological examination will be indicated. Additionally, subjective symptoms (present, absent), presence of fever, whether the infection/finding in the urine was treated or not, and whether a control urine examination was performed (performed, not performed) will be recorded. The origin of the patient (home, social care facility) and the planned surgical procedure will be noted. The Clinical Frailty Scale, type of anesthesia (general, regional), and any administered antibiotic treatment will also be recorded.
After the surgical procedure, the occurrence of urinary infection (yes, no, sample not taken) will be assessed. Postoperative complications such as fever, circulatory instability, development of delirium, infection, septic state, and death will be monitored. The trajectory of the respondent during hospitalization (which departments they will be treated in, including the length of hospitalization) will be recorded. The primary goal will be to determine the relationship between the preoperative occurrence of urinary infection or colonization in patients within the last 30 days before the procedure and the occurrence of predefined postoperative complications. Secondary goals will include identifying the most common postoperative complications in patients with preoperative urinary colonization or proven urinary infection. Additionally, the relationship between the preoperative Clinical Frailty Scale in the defined patient population and the occurrence of predefined postoperative complications will be examined. The final secondary goal will be to determine preoperative antibiotic therapy in the preoperative period.
The cohort of traumatology patients undergoing surgical procedures was chosen to ensure the homogeneity of the studied population (seniors over 65 undergoing bone surgery).
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| Measure | Description | Time Frame |
|---|---|---|
| Urinary tract infection preoperatively - signs and symptoms | Signs and symptoms include dysuria, frequency, urgency, or/and fever or/and smelling urine and non-specific signs (nausea, malaise) | one week before surgery |
| Urinary tract infection preoperatively - urinary dipstick test. | Positive urine dipstict test (i.e. nitrate-reductace and leukocyte esterase detection). | one week before surgery |
| Urinary tract infection preoperatively - chemical examination of the urine and sediment - pH | Positive result in chemical examination of the urine and the sediment for the possibility of infection s: pH ≥ 6. | one week before surgery |
| Urinary tract infection preoperatively: chemical examination - proteinuria (urine dipstick test) | Detection of proteinuria with urine dipstick test. | one week before surgery |
| Urinary tract infection preoperatively - leukocytouria (urine dipstick test) | Positive result t is leukocyturia (detection of leucocyte esteras) in a dipstick test. | one week before surgery |
| Urinary tract infection preoperatively chemical examination of the urine and sediment -pyuria (urine dipstick test) | Pyuria, which is the presence of white blood cells in the urine, will detected through these methods: Postive urine dipstick test - showing leukocyte esterase or nitrites. And additionally have to present: discoloration, clouding or change in the smell of urine for a pyuria | one week before surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical frailty scale (CFS) preoperatively | The CFS is a nine-point scale based on clinical evaluation of mobility, energy, physical activity, and function. Clinical Frailty Scale Components: 1. Very fit, 2. Well, 3. Managing Well:, 4. Living With Very Mild Frailty, 5. Living with Mild Frailty: 6. Living With Moderate Frailty, 6. Living With Severe Frailty, 8. Living with Very Severe Frailty, 9. Terminally Ill |
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Inclusion Criteria:
Exclusion Criteria:
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For seniors over 65 years (including), undergoing surgery (bone procedure, traumatology, orthopedics) in an acute or elective mode, the relationship between preoperative infection/colonization of the urinary tract (within 30 days before the procedure) and the occurrence of predefined postoperative complications will be monitored.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Klára Nekvindová, M.D., Ph.D. | Contact | +420 577 551 111 | nekvindova.klara@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tomas Bata Hospital | Recruiting | Zlín | 76001 | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30899708 | Background | Parvizi J, Koo KH. Should a Urinary Tract Infection Be Treated before a Total Joint Arthroplasty? Hip Pelvis. 2019 Mar;31(1):1-3. doi: 10.5371/hp.2019.31.1.1. Epub 2019 Mar 5. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Mar 1, 2025 | Mar 9, 2025 | Prot_000.pdf |
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| ID | Term |
|---|---|
| D014552 | Urinary Tract Infections |
| D004194 | Disease |
| D000073496 | Frailty |
| D007239 | Infections |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Urinary tract infection preoperatively: chemical examination of the urine and sediment -bacteriuria (urine dipstick test) | Presence of bacteriuria (presence of bacteria in the urine). Can be detected through urine dipstick test (determination of presence of leukocyte esterase and nitrites, which are indicators of white blood cells and bacteria in the urine) | one week before surgery |
| Urinary tract infection preoperatively - chemical examination preoperatively - chemical examination of the urine and sediment -bacteriuria | Presence of bacteriuria (presence of bacteria in the urine). Can be detected through through flow cytometry (this method detects bacteria in urinary samples in the range from 40 up to 1000/μl), | one week before surgery |
| Urinary tract infection preoperatively: chemical examination of the urine and sediment -bacteriuria (urine culture) | Presence of bacteriuria (presence of bacteria in the urine). Can be detected through urine culture (bacteria grow from a urine sample, cutoff is for a significant bacterial count is typically greater than 100,000 colony-forming units (CFU) per mililiter). | one week before surgery |
| Urinary tract infection preoperatively - chemical examination preoperatively - chemical examination of the urine and sediment - proteinuria | Detection of proteinuria with the sulfosalicylic acid test in laboratory. A semiquantitative scale is used for evaluation:
| one week before surgery |
| Urinary tract infection preoperatively - leukocytouria (sediment) | Positive result is finding in the in sediment more than 10 leukocytes per field of view. | one week before surgery |
| Urinary tract infection preoperatively chemical examination of the urine and sediment -pyuria (microscopy) | Pyuria, which is the presence of white blood cells in the urine, will detected through these methods: Microscopy - cell counts performer by microscopy, positive finding is more than 10 leukocytes per field of view. And additionally have to present: discoloration, clouding or change in the smell of urine for a pyuria. | one week before surgery |
| Urinary tract colonization preoperatively - asymptomatic bacteriuria, women (urine culture) | Midstream clean catch urine specimen will be needed. Two consecutive specimens with isolation of the same bacteria species with at least 100,000 colony-forming units (CFUs) per ml of urine. | one week before surgery |
| Urinary tract colonization preoperatively - asymptomatic bacteriuria, men (urine culture) | Midstream clean catch urine specimen will be needed. For men, a single specimen with isolation of one bacteria species with at least 100,000 CFUs per ml of urine. | one week before surgery |
| Urinary tract colonization preoperatively - asymptomatic bacteriuria, catheterized specimen (urine culture)) | For women or men, a single specimen with isolation of one bacteria species with at least 100 CFUs per ml of urine. | one week before surgery |
| Antibiotic therapy before the surgery | Preoperative antibiotic use will be recorded. Options yes, no. If yes, the type of antibiotic used will be recorded. | one week before surgery |
| Postoperative complications - fever | Fever is defined as a body temperature above 38 degrees Celsius | one week after surgery |
| Postoperative complications -circulatory instability | Presence of hypotension, MAP below 70 mm Hg | one week after surgery |
| Postoperative complications -I nfection | Presence of infection and origin of the infection in laboratory findings and in clinical picture. | one week after surgery |
| Postoperative complications - sepsis | Presence of sepsis and origin of the infection in laboratory findings and in clinical picture. | one week after surgery |
| Postoperative complications -postoperative delirum | Presence of postoperative delirium. To determine the diagnose CAM-ICU will be used. | one week after surgery |
| Postoperative complications - antibiotic | Administered antibiotic treatment and its duration | one week after surgery |
| one week before surgery |
| Preoperative antibiotic therapy | Preoperatively, it will be assessed whether the patient received antibiotic treatment for a urinary tract infection prior to surgery. The result will be recorded as yes or no. | one week before surgery |
| D052801 | Male Urogenital Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |