Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)

Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)

The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP). The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 18 years old diagnosed with severe CAP. The main question is whether there is a difference in all cause mortality within thirty days.

Participants will be randomized to receive treatment with either hydrocortisone or prednisolone.

Inclusion Criteria:

• Age > 18 years
• Diagnosis of severe CAP for who the physician in charge decides for corticosteroid therapy for severe CAP.

Exclusion Criteria:

• Admitted >24 h
• Pregnant or breastfeeding women
• Active tuberculosis or fungal infection
• Pneumonia caused by influenza
• Intolerance to either study drug