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The goal of this feasibility randomized controlled trial is to investigate the applicability of software that aims to improve symptoms of frailty by implementing customized interventions such as physical exercise and cognitive training implemented through a mobile app for 16 weeks for patients diagnosed with frailty or prefrailty. The primary outcomes are adherence, retention rates, and recruitment rates. Participants will participate in customized interventions including physical exercise, cognitive training, nutritional guidance, and management of disease related to frailty for 16 weeks.
The physical exercise program will comprise aerobic exercise, balance-improving exercises, flexibility-enhancing activities, and strength-building exercises targeting major muscle groups through a mobile app . Customized cognitive training, performed using a mobile app, targets the cognitive domains of prospective memory and executive function. Nutritional intervention will be performed to treat frailty symptoms and disease related to frailty through a mobile app. Education and management of disease related to frailty will be done through a mobile app.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | Participants will receive interventions including exercise, cognitive training, nutrition education, and management of diseases related to frailty via the app for one hour per day, five days a week for 16 weeks. |
|
| Control | No Intervention | Participants in the control group will receive standard treatment related to frailty during the study period and be provided with guidelines on 'Lifestyle habits for treating frailty or prefrailty'. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lifestyle Management | Behavioral | For 16 weeks, participants will receive exercise, cognitive training, nutrition education, and disease education through a smartphone app, and the content and intensity of the intervention will be adjusted every four weeks through an assessment of frailty symptoms through the app. |
| Measure | Description | Time Frame |
|---|---|---|
| retention rate | retention rate ≥ 70% | From enrollment to the end of intervention at 16 weeks |
| Adherence to the protocol | Adherence to the protocol ≥ 70% | From enrollment to the end of intervention at 16 weeks |
| recruitment rate | recruitment rate ≥ 50%. | From enrollment to the end of intervention at 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Korean Frailty Index for Primary Care at 16 weeks | The score ranges from 0 to 1. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Modified Fried frailty phenotype score at 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Seong Hye Choi, MD, PhD | Contact | 82 10-3120-2947 | sseonghye@inha.ac.kr |
| Name | Affiliation | Role |
|---|---|---|
| Seong Hye Choi, MD, PhD | Inha University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inha University Hospital | Recruiting | Incheon | 22332 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41509872 | Derived | Jung S, Kang HJ, Moon SY, Choi M, Jung J, Kim HR, Jung S, Jeong JH, Choi SH, Park YK. South Korean study to prevent the progression of frailty and aging-related diseases using a digital multidomain intervention (SUPERAGING): Protocol of a feasibility pilot study. Digit Health. 2026 Jan 6;12:20552076251410995. doi: 10.1177/20552076251410995. eCollection 2026 Jan-Dec. |
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Individual participant data will be shared with the Global Alzheimer's Association Interactive Network.
The data will become in 2027 and become available for 5 years.
The access criteria is an approval of steering committee.
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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The score ranges from 0 to 5. A lower score indicates better performance. |
| From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Lubben Social Network Scale at 16 weeks | The score ranges from 0 to 50. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in 14-item cognitive subscale of the Alzheimer's Disease Assessment Scale at 16 weeks | The score ranges from 0 to 90. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Korean Mini-Mental State Examination-2 at 16 weeks | The score ranges from 0 to 30. A higher score indicates better performance. | From enrollment to the end of intervention at 16 weeks |
| Change from Baseline in Clinical Dementia Rating scale-Sum of Boxes at 16 weeks | The score ranges from 0 to 18. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Korean Instrumental Activities of Daily Living at 16 weeks | The score ranges from 0 to 3. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Modified Barthel Index: at 16 weeks | The score ranges from 0 to 100. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Center for Epidemiological Studies-Depression Scale at 16 weeks | The score ranges from 0 to 60. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Quality of life-Alzheimer's disease at 16 weeks | The score ranges from 0 to 52. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in gait speed at 16 weeks | A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Short Physical Performance Battery at 16 weeks | The score ranges from 0 to 12. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline inTimed Up and Go test at 16 weeks | A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in 30 s sit-to-stand at 16 weeks | A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in 2 min stepping test at 16 weeks | A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Mini Nutritional Assessment at 16 weeks | The score ranges from 0 to 14. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in Nutritional Quotient for Elderly at 16 weeks | The score ranges from 0 to 100. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from Baseline in skeletal muscle mass at 16 weeks | A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Number of Participants with Treatment-Related Adverse Events | A lower score indicates better performance. | From enrollment to the end of intervention at 16 weeks |
| Change from baseline in MIND diet checklist at 16 weeks | The score ranges from 0 to 15. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in International Physical Activity Questionnaire-Short Form at 16 weeks | The score ranges from 0 to 20,000. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in LDL-C at 16 weeks | The score ranges from 0 to 300. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in HDL-C at 16 weeks | The score ranges from 0 to 200. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in HbA1c at 16 weeks | The score ranges from 0 to 30. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in eGFR at 16 weeks | The score ranges from 0 to 200. A higher score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in blood pressure at 16 weeks | The score ranges from 0 to 250. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in body weight at 16 weeks | The score ranges from 0 to 200. A higher score indicates better performance in frailty. | From baseline to the end of intervention at 16 weeks |
| Change from baseline in waist circumference at 16 weeks | The score ranges from 0 to 200. A higher score indicates better performance in frailty. | From baseline to the end of intervention at 16 weeks |
| Occurrence of aging-related diseases | The score ranges from 0 to 10. A lower score indicates better performance. | From baseline to the end of intervention at 16 weeks |
| Ewha Womans University Seoul hospital | Not yet recruiting | Seoul | South Korea |
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| Ajou University Hospital | Not yet recruiting | Suwon | South Korea |
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