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The goal of this single-center prospective observational study is to identify and evaluate new biomarkers for ischemic cerebrovascular disease (ICVD) to aid in early diagnosis, individualized treatment planning, and prognosis prediction in affected patients. The main questions it aims to answer are:
Can specific biomarkers help in identifying high-risk individuals before disease onset? Can these biomarkers predict disease progression and treatment response? Researchers will compare patients diagnosed with ICVD and healthy controls from a medical check-up center to assess differences in biomarker expression and their clinical significance.
Participants will:
Provide blood, cerebrospinal fluid, urine, and stool samples for biomarker analysis.
Undergo clinical imaging (CT, MRI, PET-CT) and functional assessments. Be followed up at 3, 6, 12, 24, 36, and 48 months for clinical outcomes and biomarker changes.
This study aims to develop a comprehensive biomarker-based prediction model to enhance the diagnosis and management of ischemic cerebrovascular disease.
The detaited information about this trial is described below
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ischemic cerebrovascular disease | clinical diagnosis with ischemic cerebrovascular disease |
| |
| health control | age- and sex-matched control individuals |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biomaker levels | Diagnostic Test | this study will discover and validate novel biomarkers (including urine, feces, cerebrospinal fluid, blood, plaques, emboli, drainage fluid, bone marrow, lymph nodes and brain tissue etc al) of ischemic cerebrovascular disease |
| Measure | Description | Time Frame |
|---|---|---|
| all-cause mortality | Death during the follow-up in every single reason | 10 years |
| Stroke of any kind | Brain CT or MRI scans will be used to measure whether there is any kind of stroke, including TIA, ischemic stroke, and hemorrhage | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Rehospitalization | The rehospitalized times of any circumstances except for admission to hospital only for examination per year will be used to measure the situation | 10 years |
| National Institute of Health stroke scale (NIHSS score) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with ischemic cerebrovascular disease admission to Department of Neurology and Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from Janurary 1, 2025 - December 31, 2035
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luo-Qi Zhou | Contact | 86-27-83663337 | zhouluoqi@tjh.tjmu.edu.cn | |
| Xiaowei Pang | Contact | 86-27-83663337 | pangxiaowei1998@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Dai-Shi Tian | Tongji Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, | Not yet recruiting | Wuhan | Hubei | 430030 | China |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Collect samples of urine, fecal, cerebrospinal fluid, blood, plaques, emboli, drainage fluid, bone marrow, lymph nodes, pia mater, dura mater and brain tissue etc.al from patients
The minimum value is 0, and maximum value is 42, and higher scores mean a worse outcome.
| 10 years |
| modified Ranking score (mRS) | The minimum value is 0, and maximum value is 6, and higher scores mean a worse outcome. | 10 years |
| Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, | Recruiting | Wuhan | Hubei | 430030 | China |
|
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |