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A prospective, single-center, observational study aiming to assess the predictive role of flow mediated dilatation in acute coronary syndromes, combined with echocardiographic and biochemical indices. The novel Cor-IS technology will also be evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observation group | Patients hospitalized due to acute coronary syndromes (STEMI, NSTEMI) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observation group | Diagnostic Test | Patients with acute coronary syndrome undergo endothelial function assessment using two methods (flow mediated dilatation of the brachial artery and Cor-Is technology) transthoracic echocardiogram and plasma biomarkers' measurement. |
| Measure | Description | Time Frame |
|---|---|---|
| Brachial artery endothelial function assessment using the Cor-IS method compared to FMD | The primary outcome of the study is the assessment of brachial artery endothelial function in the therapeutic approach using the Cor-IS method compared to the reference method FMD. The indices of the FMD method (FMD%, shear rate, and FMD/shear) will be compared with the R index of the Cor-IS method at the study's baseline and during follow-up. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| FMD% index and MACE | Correlation of the FMD% index with the 3-point MACE (cardiovascular death, non-fatal acute myocardial infarction, stroke) | 12 months |
| R-index and MACE | Correlation of the R-index with the 3-point MACE (cardiovascular death, non-fatal acute myocardial infarction, stroke). |
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Inclusion Criteria:
Exclusion Criteria:
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Patients hospitalized due to acute coronary syndromes (STEMI, NSTEMI) are considered eligible for the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christodoulos E. Papadopoulos, PhD | Contact | 2313312343 | +30 | chrpapado@gmail.com |
| Georgios Zormpas, MD | Contact | 2313312343 | +30 | sparky.zorb@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Christodoulos E. Papadopoulos, PhD | Aristotle University of Thessaloniki, Greece | Principal Investigator |
| Georgios Zormpas, MD | Aristotle University of Thessaloniki, Greece | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ippokratio General Hospital | Recruiting | Thessaloniki | 54642 | Greece |
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40 ml plasma specimen (-80 grades Celsius)
| 12 months |
| FMD% index and rehospitalizations for angina | Correlation of the FMD% index with the total rehospitalizations for angina. | 12 months |
| R-index and rehospitalizations for angina | Correlation of the R-index with the total rehospitalizations for angina. | 12 months |
| FMD% index and need for revascularization | Correlation of the FMD% index and need for revascularization within 1 year from study enrollment. | 12 months |
| R-index and need for revascularization | Correlation of the R-index and need for revascularization within 1 year from study enrollment. | 12 months |
| FMD% index and heart failure | Correlation of the FMD% index and the development of heart failure within 1 year from study enrollment. | 12 months |
| R-index and heart failure | Correlation of the R-index and the development of heart failure within 1 year from study enrollment. | 12 months |
| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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