This is a prospective, multicenter, case-control study. The aim is to develop an optimized algorithm by combining the levels of molecular markers in plasma together with risk factors for developing colorectal cancer and clinical data of patients diagnosed with CRC or AA and healthy individuals.

Inclusion Criteria:

• Patients over the age of 18 who are able to understand the participant information and sign the informed consent.
• Patients who are going to undergo colonoscopy or surgical resection for tumor (CRC).

Exclusion Criteria:

• Patients who had developed any type of cancer in the 5 years prior to their participation in this study.
• Patients who have received previous chemotherapy or radiotherapy.
• Patients diagnosed with non-advanced adenomas, serrated polyps, Familial Adenomatous Polyposis or Lynch Syndrome.
• Patients with inadequate bowel preparation for colonoscopy.
• Patients who have undergone colonoscopy/polipectomy in the previous 5 years.
• Patients with hemolyzed plasma.

This study involves the recruitment of 510 patients as part of a case-control study. Patients who are going to undergo colonoscopy or who are going to undergo surgery for resection of a CRC already diagnosed will be included. They can be symptomatic or asymptomatic, ambulatory, hospitalized or consecutive patients in the Endoscopy Unit.