Central Venous Pressure (CVP) is a standard parameter for hemodynamic monitoring and is currently measured through the insertion of a catheter. The pediatric population is especially vulnerable to risks associated to this invasive procedure, including infection, thrombosis, and pneumothorax. The proposed pilot study will evaluate safety and preliminary efficacy of a new non-invasive ultrasound-based venous occlusion pressure (VOP) monitoring device (CPMX2) in children equipped with an invasive catheter for CVP monitoring as part of standard of care.

Inclusion Criteria

• Provision of signed and dated informed consent form
• Male or female
• Age: birth to 21 years of age
• Equipped with a central venous catheter (CVC) for central venous pressure (CVP) monitoring indication as part of standard of care, or undergoing cardiac catheterization.

Exclusion Criteria:

• Weight less than 2.5kg at the time of enrollment.
• Bilateral external jugular veins not accessible due to vascular access or dressing.
• Bilateral skin lesion contraindicating neck Ultrasound
• Active bleeding
• Clinically unstable, per clinical assessment by attending physician and/or surgeon

The investigator performing the measurement with CPMX2 is blinded to the invasive CVP measurement until the assessment is complete.