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The goal of this observational retrospective study is to assess the impact of hepatitis B virus (HBV) infection on the clinical course and outcomes of inflammatory bowel disease (IBD) in Egyptian patients.
Researchers will compare the IBD extent, location, severity, and behavior between IBD patients with and without HBV infection.
Participants will be subjected to history-taking (history of hospital admission and disease flare, surgical history, medication history, follow-up duration, and mortality), clinical examination, laboratory investigations, abdominal ultrasonography, and endoscopic examination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IBD patients with positive HBV infection. | 81 IBD patients with positive HBV infection. |
| |
| IBD Patients with negative HBV infection | 81 IBD Patients with negative HBV infection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| History of IBD course and outcome in HBV patients | Other | Full history taking including:
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with severe IBD measured by Truelove-Witts severity index | comparing IBD extent, location, and behavior using Montreal classification, Truelove-Witts severity index between patients with and without HBV infection | through study completion, an average of 6 month |
| Hospital admission rates in IBD patients | comparing IBD hospital admission rates between patients with and without HBV infection | through study completion, an average of 6 month |
| number of IBD patients undergoing surgical treatment | comparing surgical treatment rates (intestinal resection in CD patients and total proctocolectomy in UC patients) for IBD between patients with and without HBV infection | through study completion, an average of 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Disease flares rates in IBD patients | comparing IBD disease flare rate between patients with and without HBV infection. | through study completion, an average of 6 months |
| mortality rates in IBD patients |
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Inclusion Criteria:
Exclusion Criteria:
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IBD patients attending the Tanta Tropical Medicine Department, Faculty of Medicine.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rania M Elkafoury, MD | Contact | +201004672358 | rania.elkafoury@med.tanta.edu.eg | |
| Nabila A Elgazzar, MD | Contact | 00201288585733 | nabilaelgazzar@med.tanta.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Nabila A Elgazzar, MD | Tropical medicine and infectious diseases Department, Faculty of Medicine, Tanta University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University Hospitals | Recruiting | Tanta | Gharbyea | 31516 | Egypt |
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D006509 | Hepatitis B |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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|
comparing IBD mortality rates between patients with and without HBV infection.
| through study completion, an average of 6 months |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D018347 | Hepadnaviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D006525 | Hepatitis, Viral, Human |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |