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This is a multicenter, randomized, open-label, parallel-controlled, prospective clinical study. It aims to evaluate the efficacy and safety of aerosolized Peginterferon α-2b injection in the treatment of pediatric respiratory syncytial virus pneumonia. The overall study is divided into a screening period, a treatment period, and a follow-up period. Eligible children with respiratory syncytial virus pneumonia will be randomly assigned to the experimental group 1, experimental group 2, and the control group at a ratio of 1:1:1.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peginterferon α-2b 45 mcg dose group | Experimental |
| |
| Peginterferon α-2b 90 mcg dose group | Experimental |
| |
| Control group | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Peginterferon α-2b injection | Drug | Peginterferon α-2b injection, 45 mcg, neb.On the 1st, 3rd, and 5th day, take the medication,while providing symptomatic and supportive treatment simultaneously. |
| Measure | Description | Time Frame |
|---|---|---|
| Time for the disappearance of major clinical symptoms | Major clinical symptoms include fever, cough, wheezing, increased respiratory rate, and moist rales in the lungs | Day 6 |
| The time of disappearance of abnormal signs. | Abnormal signs include fever, cough, wheezing, increased respiratory rate, and moist rales in the lungs. | Day 6 |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the differences in treatment efficacy rates among the various groups. | Day 6 | |
| Compare the differences in the proportions of primary clinical symptoms alleviated/disappeared among the various groups. | Day3,5. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lina Chen, Ph.D | Contact | 028-88570522 | chenln66@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Lina Chen, Ph.D | West China Second University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chengdu Women's and Children's Central Hospital | Recruiting | Chengdu | Sichuan | China |
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| Peginterferon α-2b injection | Drug | Peginterferon α-2b injection, 90 mcg, neb.On the 1st, 3rd, and 5th day, take the medication,while providing symptomatic and supportive treatment simultaneously. |
|
| symptomatic and supportive treatment | Behavioral | symptomatic and supportive treatment |
|
| Compare the differences in the proportions of abnormal physical signs alleviated or disappeared among the various groups. | Day3,5. |
| Compare the differences in the time curves for the normalization of major clinical symptoms among the various groups. | Day6 |
| Compare the differences in the time curves for the normalization of major abnormal physical signs among the various groups. | Day6 |
| Compare the differences in total hospitalization duration among the various groups. | Day6 |
| West China Second University Hospital of Sichuan University | Recruiting | Chengdu | Sichuan | China |
|