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This pilot study examines the use of thromboelastography (TEG), a specialized blood test, to evaluate clotting abnormalities in burn patients. The study aims to understand how burn injuries impact the body's ability to form and break down blood clots over time. Specifically, the investigators will research whether the percentage of total body surface area burned (%TBSA) is associated with changes in blood clotting, track the evolution of clotting patterns during the first four weeks following a burn injury, and explore whether these changes can predict recovery or complications. By providing new insights into clotting dynamics in burn patients, the study seeks to improve diagnostic methods, enhance monitoring strategies, and guide treatments to optimize patient care and outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Burn Thromboelastography Group | Experimental | Overall study population (all participants are in the same group). See eligibility for further details. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thromboelastography | Diagnostic Test | All participants will receive this intervention. Thromboelastography (TEG) is a blood test that provides a detailed assessment of the clotting process, measuring how blood clots form, strengthen, and dissolve. It offers real-time insights into a patient's coagulation status, helping to identify clotting disorders and guide treatment decisions. |
| Measure | Description | Time Frame |
|---|---|---|
| Thromboelastography | Thromboelastography (TEG) evaluates blood's clotting ability by measuring the strength and elasticity of a clot over time, producing a dynamic graph. The following outcome measures will be assessed at specific time points (Day 1, Day 7, Day 14, Day 21, and Day 28):
Each parameter will be measured at the specified time points, and values will be aggregated into one TEG graph. | Duration of hospital length of stay, up to 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital Length of Stay | The investigators will measure the number of days patients stay in the hospital for treatment. | Duration of hospital length of stay, up to 28 days |
| Complications During Treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Francesco M Egro, MD | Contact | (404) 861-7944 | egrofm@upmc.edu | |
| Hilary Y Liu, BS | Contact | 4846315188 | liuh23@upmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Francesco M Egro, MD, MSc, MRCS | Department of Plastic Surgery, University of Pittsburgh Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15219 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15639372 | Background | Baumeister S, Koller M, Dragu A, Germann G, Sauerbier M. Principles of microvascular reconstruction in burn and electrical burn injuries. Burns. 2005 Feb;31(1):92-8. doi: 10.1016/j.burns.2004.07.014. | |
| 39129846 | Background | Alessandri-Bonetti M, Kasmirski JA, Liu HY, Corcos AC, Ziembicki JA, Stofman GM, Egro FM. Impact of Microsurgical Reconstruction Timing on the Risk of Free Flap Loss in Acute Burns: Systematic Review and Meta-Analysis. Plast Reconstr Surg Glob Open. 2024 Aug 9;12(8):e6025. doi: 10.1097/GOX.0000000000006025. eCollection 2024 Aug. |
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De-identified individual participant data (IPD) will be shared upon reasonable request by the peer-reviewed journal in which this study is published, provided the request is in alignment with ethical and legal standards.
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| ID | Term |
|---|---|
| D002056 | Burns |
| D013927 | Thrombosis |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D013916 | Thrombelastography |
| ID | Term |
|---|---|
| D001780 | Blood Coagulation Tests |
| D006403 | Hematologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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The investigators will record any complications, such as infections, graft loss, flap loss, or thrombosis that occur during treatment.
| Duration of hospital length of stay, up to 28 days |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |