This clinical study aims to evaluate a breakthrough treatment for hair loss (androgenetic alopecia, AGA) using dissolvable threads placed under the scalp skin. The investigators hypothesize that these specially designed threads can improve hair growth, avoiding the need for invasive surgery.

Current AGA treatments taken orally often have limitations, prompting researchers to explore localized approaches. While early studies show promise for localized scalp thread embedding, three key challenges remain: 1) No standardized way to measure effectiveness, 2) Lack of objective biological markers to track progress, and 3) Limited understanding of how exactly these treatments work.

This study addresses these gaps through precise thread placement in balding areas, following international dermatology guidelines. Using advanced measurement tools, the investigators will track changes in hair thickness (primary measure), blood flow patterns under the skin, and oil gland activity (secondary measures). By focusing on one key treatment factor, this research provides the first comprehensive evidence showing how this minimally invasive approach may slow or reverse AGA progression.

Inclusion Criteria:

• Male sex
• Age 18-50 years
• No clinically significant comorbidities
• Androgenetic alopecia (Hamilton-Norwood III-V)
• No systemic anti-hair loss therapy use within 3 months
• No topical hair regrowth agent use within 3 months

Exclusion Criteria:

• Active scalp infection
• Scalp psoriasis
• Scalp eczema
• Open scalp wounds
• Allergy to thread materials
• Uncontrolled diabetes mellitus
• Immunodeficiency disorders
• Non-compliance with follow-up visits
• Refusal to provide informed consent
• Investigator-deemed contraindications