Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

AMP-C: A Digital Therapeutic for Reward Dysfunction in Co-Occurring Depression and Cannabis Use

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.

Inclusion Criteria:

• Aged ≥ 18 years
• Resides in the United States
• Able to read and understand English and willing to provide informed consent/comply with the study protocol
• Moderate depressive symptom severity, as indicated by the Patient Health Questionnaire-9 (PHQ-9)
• Problematic cannabis use, as indicated by the Cannabis Use Disorder Identification Test - Revised (CUDIT-R)
• Current elevated anhedonia, as indicated by the PHQ-9
• Interest in receiving treatment for their cannabis use and depression
• Meet criteria for current MDD and CUD per the DSM-5

Exclusion Criteria:

• History of a psychotic disorder or bipolar disorder type I/II
• Active suicidal ideation or intent based on the Columbia-Suicide Severity Rating Scale
• Current psychotherapy engagement
• Changes in psychotropic medication within six weeks of the start of study