This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.

Inclusion Criteria:

• diagnosed with non-STEMI
• Patients aged 18 to 75 years
• positive troponin levels,
• blood pressure above 120/70 mmHg

Exclusion Criteria:

• Hemodynamically unstable and requiring urgent intervention,
• ST elevation on electrocardiography, atrial fibrillation,
• recurrent angina,
• use of narcotic analgesics (e.g., morphine), nitrates and glycoprotein IIb/IIIa inhibitors during hospitalization,
• history of coronary artery bypass graft (CABG) surgery,
• active infection,
• uncontrolled hypertension,
• diabetes, cerebrovascular accident, Use P2Y12 inhibitor, proton pump inhibitor, oral anticoagulant, statin, CYP enzyme-inducing or inhibiting drugs at the time of admission,
• active systemic disease (e.g., malignancy, thyroid disorders chronic inflammatory diseases, liver dysfunction),
• left ventricular systolic dysfunction (ejection fraction <50%),
• glomerular filtration rate <60 mL/min/1.73m2,
• allergy to ASA or clopidogrel, coagulopathy,
• platelet counts below 100,000/μl and hematocrit levels below 29%, or exceeding 52%.

acute coronary syndrome patients