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| ID | Type | Description | Link |
|---|---|---|---|
| 2025-520627-25-00 | EU Trial (CTIS) Number |
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| Name | Class |
|---|---|
| Uppsala University Hospital | OTHER |
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The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.
Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis.
In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.
See the study protocol
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol | Active Comparator | Propofol Maintenance Anesthesia |
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| Sevoflurane | Active Comparator | Sevoflurane Maintenance Anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anesthesia Maintenance Agent | Drug | Difference in renal blood flow (RBF) between Propofol and Sevoflurane groups. Quantified by specific Multiparametric MRI metrics (e.g., (Renal blood flow by phase contrast imaging) (regional perfusion by Arterial Spin labeling (ASL) and global and regional oxygenation by Blood oxygen dependent signal (BOLD)) |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in RBF, as measured by phase contrast imaging with mpMRI, between propofol and sevoflurane anesthesia. | Multiparametric MRI via phase contrast imaging to quantify renal blood flow, will be standardized to renal area. By quantifying renal blood flow we will be able to evaluate the effects of propofol and sevoflurane on RBF. | The extra imaging is expected to take 20-30 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in regional renal tissue perfusion, as measured by arterial spin labelling (ASL) with mpMRI, between propofol and sevoflurane anaesthesia | To investigate the effect of Propofol and Sevoflurane on regional tissue perfusion in the renal cortex and medulla. | The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Arash Emami, PhD student | Contact | +46763222722 | arash.emami@uu.se | |
| Robert Frithiof, Professor | Contact | robert.frithiof@uu.se |
| Name | Affiliation | Role |
|---|---|---|
| Robert Frithiof, Professor | Istitution of Surgical Sciences, Anesthesiology and Intensive Care | Study Chair |
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GDPR
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| ID | Term |
|---|---|
| D000758 | Anesthesia |
| D000077149 | Sevoflurane |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D000760 | Anesthesia and Analgesia |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
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Patients are randomized to one out of two possible methods of maintenance anesthesia
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The analyzer of the MRI images of renal blood flow, quantifying volumes will be masked from the method of anesthesia.
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|
| Differences in regional and global renal oxygenation, as measured by Blood Oxygen Level Dependent (BOLD) signal via mpMRI, between propofol and sevoflurane anaesthesia. | To explore potential differences related to the Sevoflurane or Propofol on regional and global renal oxygenation. | The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images |
| The difference in relation of RBF to systemic non-invasive blood pressure, between propofol and sevoflurane anaesthesia | To investigate how RBF varies in relation to systemic blood pressure in paediatric patients in generalized anaesthesia with propofol or Sevoflurane. | The entire MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images |
| The difference plasma renin concentration, measured by a blood sample, between propofol and sevoflurane anaesthesia | To explore the effect of Sevoflurane and Propofol on serum Renin concentration as a surrogate marker for Renal sympathetic nerve activation. | 1 minute |
| D006845 |
| Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |