MR-Evaluation of Renal Function in Anesthetized Pediatric Patients

MR-Evaluation of Renal Function in Anesthetized Pediatric Patients

The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.

Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis.

In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.

See the study protocol

Inclusion Criteria:

• Pediatric Patients (1 month -14 years of age)
• Indicated for MRI with anesthesia
• ASA (American Society of Anesthesiologists) physical status I-III

Exclusion Criteria:

• Known renal impairment or chronic kidney disease
• Severe cardiac or pulmonary disease
• Allergy to either Propofol or Sevoflurane
• Contraindications to Magnetic Resonance Imaging
• Contraindications to either Propofol or Sevoflurane
• Declined participation or declined consent from patients, parents or guardians
• Ongoing acute kidney injury