Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Jomo Kenyatta University of Agriculture and Technology | OTHER |
Not provided
Not provided
Not provided
Not provided
The overall objective of this study is to determine dietary iron absorption from lipid-based nutrient supplements (LNS) in apparently healthy and undernourished children. This case-control study will recruit apparently healthy children and children with uncomplicated undernutrition (age 1-3 years, n=15/group) from Msambweni and the surrounding rural communities in Kwale County, Kenya. At the baseline visit (day 0), participants will be provided with an LNS labeled with a stable iron isotope (57-Fe). Participants will return to the hospital 14 days later (day 14) for a blood draw. Blood collected on day 14 will be used to measure iron isotope incorporation into red blood cells. Blood collected at screening will be used to measure indicators of anemia, iron status, hepcidin, and inflammation.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Apparently Healthy |
| ||
| Undernourished |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lipid-Based Nutrient Supplement | Dietary Supplement | LNS labeled with a stable iron isotope |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dietary iron absorption | Isotope incorporation into RBCs on day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Hemoglobin | Hemoglobin concentration | Measured at screening |
| Serum ferritin | Serum ferritin concentration | Measured at screening |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Participants will be recruited from Msambweni and the surrounding rural communities in Kwale County, Kenya.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Stephen Hennigar, PhD | Pennington Biomedical Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Msambweni County Referral Hospital | Msambweni | Kenya |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| Soluble transferrin receptor | Soluble transferrin receptor concentration | Measured at screening |
| Transferrin saturation | Transferrin saturation percentage | Measured at screening |
| Hepcidin | Hepcidin concentration | Measured at screening |
| C-reactive protein | C-reactive protein concentration | Measured at screening |
| Alpha-1-acid glycoprotein | Alpha-1-acid glycoprotein concentration | Measured at screening |