The aim of the study was to evaluate the response of regional anesthesia to remifentanyl consumption in patients undergoing laparoscopic cholecystectomy surgery.

Routine anesthesia and analgesia protocol will be applied to all participants. The study aims to evaluate the remifentanyl consumption of the participants by dividing them into two groups as those with and without block and then performing their monitoring (pulse, mean arterial pressure with noninvasive measurement, oxygen saturation, Analgesia Nociception Index, Bispectral index). Remifentanil level will be adjusted according to the ANI value. The target is to keep the ANI between 50-70.

Inclusion Criteria:

• Participants who will undergo elective laparoscopic cholecystectomy surgery,
• Age 18-70,
• ASA I-II physical status,
• Body mass index (BMI) < 35 kg/m²,
• Participants who have written consent to participate in the study

Exclusion Criteria:

• Participants with routine analgesic consumption,
• Those with coagulopathy,
• Those with a history of local anesthetic allergy,
• Those with cardiac arrhythmia and pacemaker,
• ASA III and above, Those with dementia

The datasets used and/ or analysed during the current study are available from the corresponding author on reasonable request.