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The purpose of this study is to evaluate the effectiveness of the Launching intervention (Pagan et al., 2024) in improving adaptive functioning, transition readiness, and social cognition in young adults with Autism Spectrum Disorder (ASD), compared to a delayed treatment control group, to examine whether the Launching intervention leads to improvements in executive functioning, co-occurring mental health symptoms, and quality of life, as measured by caregiver and self-report assessments, to assess the maintenance of treatment gains 12 weeks post-treatment and to replicate the findings of the Launching pilot study in an independent sample of young adults with ASD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Launching! to adulthood group therapy | Experimental |
| |
| No intervention then Launching! to adulthood group therapy | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Launching! to adulthood group therapy | Behavioral | Participants will be in a 12-week therapy program that includes weekly group sessions and individual coaching. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in adaptive functioning as assessed by the Adaptive Behavior Assessment System, Third Edition (ABAS-3) | This is a 239 item questionnaire and each is scored from 0(is not able to do this behavior) to 3 [(always able to do this behavior)(or almost always)] a higher number indicating better outcome | Baseline, week 12, week 24 |
| Change in social response as assessed by the Social Responsiveness Scale, Second Edition (SRS-2) | This is a 65 item questionnaire and each is scored on a 4-point Likert scale from 1(Not True) to 4(Almost Always True) for a maximum raw score of 120, higher score indicating worse outcome. | Baseline, week 12, week 24 |
| Change in transition readiness as assessed by the Transition Readiness Scale (TRS)-child version | This is a 30 item questionnaire and each is scored from 1(not true for me ) to 4(true for me) for a maximum score of 120, higher score indicating better outcome. | Baseline, week 12, week 24 |
| Change in transition readiness as assessed by the Transition Readiness Scale (TRS)-parent version | This is a 30 item questionnaire and each is scored from 1(not true for them) to 4(true for them) for a maximum score of 120, higher score indicating better outcome. | Baseline, week 12, week 24 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in executive functioning as assessed by the Behavior Rating Inventory of Executive Function, Second Edition (BRIEF-2) | This is a 75 item questionnaire and each is scored from 1(never) to 3(often) for a maximum score of 225, higher number indicating worse outcome | Baseline, week 12, week 24 |
| Change in depression as assessed by the Patient Health Questionnaire-9 (PHQ-9) for depressive symptoms |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Antonio Pagan, PhD | Contact | (713) 486-2700 | Antonio.Pagan@uth.tmc.edu | |
| Katherine Loveland, PhD | Contact | (713) 486-2587 | Katherine.A.Loveland@uth.tmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Antonio Pagan, PhD | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston | Recruiting | Houston | Texas | 77030 | United States |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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| standard of care | Behavioral | Participants will receive a list of resources |
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This is a 9 item questionnaire and each is scored from 0(not at all) to 3(nearly every day) for a maximum score of 27, higher number indicating worse outcome |
| Baseline, week 12, week 24 |
| Change in anxiety as assessed by the Generalized Anxiety Disorder-7 (GAD-7) for anxiety symptoms | This is a 7 item questionnaire and each is scored from 0(not at all) to 4(nearly every day) for a maximum score of 21 , higher score indicating more anxiety | Baseline, week 12, week 24 |
| Change in quality of life as assessed by the World Health Organization Quality of Life Brief Version (WHOQOL-BREF) | This is a 26 item questionnaire ,with 4 domains. Each is scored from 1(very poor) to 5(very good) ,questions 3,4 and 26 are reverse scored for a maximum raw score of 120 and higher score indicating better quality of life | Baseline, week 12, week 24 |
| Change in quality of life as assessed by the Autism Spectrum Quality of Life (ASQoL) questionnaire | This is a 9 item questionnaire. Each is scored on a 4-point Likert scale from 1(not at all) to 5(totally) ,questions 6,7 and 8 are reverse scored for a maximum score range of 9-36 and higher score indicating better quality of life | Baseline, week 12, week 24 |
| Change in parental stress as assessed by the Parental Stress Scale (PSS) | This is a 14 item questionnaire and each item is scored from 1 (strongly disagree) to 5 (strongly agree) for a score range of 18-90, higher score indicating more stress | Baseline, week 12, week 24 |