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The investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group. While heat stress can reduce kidney function, previous research has not accounted for physical activity, diet, hydration, or sun exposure.
Intense heat stress on the body can reduce kidney function. A recent study reported that blood markers of kidney function are lower among people in hotter climates. However, these data did not consider physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight. Therefore, the investigators invite participants to help determine whether there are seasonal changes in kidney function biomarkers. This will also help the investigators understand if physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight affect kidney function biomarkers between seasons. The investigators are studying female adults post-menopause since they are an understudied group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Winter | Assessment of the cohort in winter 2025 (visit 1). |
| |
| Summer | Assessment of the cohort in summer 2025 (visit 2). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| There will be no intervention. | Other | This research focuses on examining seasonal variations in kidney function among postmenopausal females. As an observational study, our approach is non-interventional. |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma neutrophil gelatinase-associated lipocalin (NGAL) | Changes in NGAL will be measured in blood samples using enzyme-linked immunosorbent assay. | Visit 1 (0 months) and Visit 2 (7 months) |
| Urinary neutrophil gelatinase-associated lipocalin (NGAL) | Changes in NGAL will be measured in urine samples using radioimmunoassay. | Visit 1 (0 months) and Visit 2 (7 months) |
| Insulin-like growth factor-binding protein 7 (IGFBP7)*Tissue inhibitor of metalloproteinase-2 (TIMP-2) | The product of Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2) will be measured in blood samples using enzyme-linked immunosorbent assays. | Visit 1 (0 months) and Visit 2 (7 months) |
| Measure | Description | Time Frame |
|---|---|---|
| estimated glomerular filtration rate (eGFR) | eGFR will be calculated from creatinine using CKD-EPI equation. | Visit 1 (0 months) and Visit 2 (7 months) |
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Inclusion Criteria:
Exclusion Criteria:
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Participants will be recruited from the greater Tallahassee, Florida area.
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| Name | Affiliation | Role |
|---|---|---|
| Joseph Watso, PhD | Florida State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Florida State University | Tallahassee | Florida | 32306 | United States |
Data with all HIPAA identifiers removed may be shared in future collaborative efforts pending appropriate data and/or material transfer agreement approvals.
One year after completion of the trial, indefinitely
A formal plan identifying the intended use of the data and proper completion of appropriate data and/or material transfer agreement approvals with the study PI and their institution.
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 24, 2026 |
| ID | Term |
|---|---|
| D018882 | Heat Stress Disorders |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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Blood samples and urine samples