Individuals with MG (IwMG) experience shortness of breath that may be activity-related, occur at rest and even happen during sleep. Dyspnea is a complex, multidimensional and multifactorial symptom involving sensory perception, cognition and emotion. Identifying the cause(s) of dyspnea in MG may assist in finding therapeutic strategies, reducing discomfort, improving QoL and potentially limiting respiratory deterioration and incidence of MG crisis.

MYaResp is a prospective observational, cross-sectional study to evaluate dyspnea in adults with autoimmune myasthenia gravis.

Study aims include to:

• Describe the characteristics of dyspnea in IwMG
• Understand contributing factors and factors associated with dyspnea in IwMG including the relationship between patient-reported dyspnea, disease severity and functional limitations.
• Determine the most effective tests to identify the causes and contributing factors of dyspnea

Inclusion Criteria:

• Age ≥18
• Confirmed diagnosis of autoimmune MG
• Shortness of breath in daily life: score 1 or 2 on the respiration item on the MG- activities of daily living score
• Signed consent form
• Affiliated to or beneficiary of a social security scheme

Exclusion Criteria:

• Known Pregnancy
• Known respiratory disorder (other than MG)
• Recent (within past 4 weeks) respiratory infection
• Current MG crisis or exacerbation (necessitating increase in MG medication &/or hospital admission)
• No dyspnea - score 0 or 3 on the respiration item on the MG- activities of daily living score
• Severe cognitive impairment/guardianship

Age ≥18 Confirmed diagnosis of autoimmune MG Shortness of breath in daily life: score 1 or 2 on the respiration item on the MG- activities of daily living score