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| Name | Class |
|---|---|
| INSERM UMR 1322 LINC | UNKNOWN |
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The goal of this exploratory, interventional, multicentre study is to compare the prefrontal activity during a negative emotion regulation task in women with Binge-Eating Disorder (BED) and healthy women with and without Emotional Eating (EE).
The aim of this study is to compare the prefrontal processing of cognitive control of emotions between BED and EE and to compare the emotional processing and emotional experience between BED and EE.
The study will thus compare four experimental groups: patients with BED, BMI-matched healthy volunteers with EE, BMI-matched healthy volunteers, and healthy volunteers of normal weight without BED.
Participants will perform a down-regulation task of negative emotions elicited by negative pictures. During this task, their cerebral activity will be recorded using functional near-infrared spectroscopy (fNIRS), as well as their autonomous activity (skin conductance, pulse rate, respiration rate).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with binge eating desorders | Experimental | Patients with binge eating desorders |
|
| healthy volunteers with a low score at the emotion eating scale compare to median | Experimental | group matched with patients for age and body mass index |
|
| healthy volunteers with a high score at the emotion eating scale compare to median | Experimental | group matched with patients for age and body mass index |
|
| healthy volunteers normo-weight group with a low score at the emotion eating scale compare to median | Experimental | healthy volunteers with normo-weight group matched with patients only in age but not in Body Mass Iindex with an Emotional Eating score below the median |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Emotion regulation task (fNIRS recording during the emotional regulation task) | Behavioral | No drugs were used in this study. All participants perform an emotion regulation task. More precisely, they have to down regulate negative emotions elicited by negative pictures using a cognitive reaprasal strategy. To this end, they have to change the meaning of the picture they are watching in order to decrease motional intensity. |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of prefrontal cortex activity using functional near-infrared imaging (fNIRS). | The fNIRS signal represents the concentration of oxyhemoglobin and deoxyhemoglobin over time. It provides information about the local oxygen demand of the brain and therefore its activity. It is these concentrations during the regulatory task that are used as the primary outcome measure. | Day 1 during the viewing of images with negative valence |
| Measure | Description | Time Frame |
|---|---|---|
| Psychophysiological measurements: electrodermal activity | Skin conductance measures are recorded These provide information on the autonomic nervous system (sympathetic and parasympathetic) and thus on emotional processing and arousal. | Day 1 during the viewing of images with negative valence |
| Psychophysiological measurements: electrocardiogram |
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Inclusion Criteria:
Non inclusion Criteria:
Healthy volunteers only :
All subjects (healthy volunteers and patients) :
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| BILLOT Pierre-Edouard, PhD | Contact | +33363082216 | pierre-edouard.billot@univ-fcomte.fr | |
| POZET Astrid | Contact | +33381218988 | apozet@chu-besancon.fr |
| Name | Affiliation | Role |
|---|---|---|
| AMSALLEM Anne-Cécile, MD | CHU de Besançon | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UFC - UFR Santé | Recruiting | Besançon | 25000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36995567 | Background | Parker MN, Burton Murray H, Piers AD, Muratore A, Lowe MR, Manasse SM, Ayaz H, Juarascio AS. Prefrontal cortex activation by binge-eating status in individuals with obesity while attempting to reappraise responses to food using functional near infrared spectroscopy. Eat Weight Disord. 2023 Mar 30;28(1):34. doi: 10.1007/s40519-023-01558-z. | |
| 29165348 |
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It is important to note that no drugs are tested. The task (emotion regulation) is consistent for all groups.
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|
Electrocardiogram measures are recorded These provide information on the autonomic nervous system (sympathetic and parasympathetic) and thus on emotional processing and arousal. |
| Day 1 during the viewing of images with negative valence |
| Psychophysiological measurements: respiratory rate | Respiratory rate is recorded These provide information on the autonomic nervous system (sympathetic and parasympathetic) and thus on emotional processing and arousal. | Day 1 during the viewing of images with negative valence |
| CHU de Besançon | Not yet recruiting | Besançon | 25030 | France |
|
| CHU de Dijon | Recruiting | Dijon | 21000 | France |
|
| Dingemans A, Danner U, Parks M. Emotion Regulation in Binge Eating Disorder: A Review. Nutrients. 2017 Nov 22;9(11):1274. doi: 10.3390/nu9111274. |
| 37950264 | Background | Arexis M, Feron G, Brindisi MC, Billot PE, Chambaron S. A scoping review of emotion regulation and inhibition in emotional eating and binge-eating disorder: what about a continuum? J Eat Disord. 2023 Nov 10;11(1):197. doi: 10.1186/s40337-023-00916-7. |
| ID | Term |
|---|---|
| D056912 | Binge-Eating Disorder |
| D000098382 | Emotional Eating |
| D000080103 | Emotional Regulation |
| D001068 | Feeding and Eating Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D005247 | Feeding Behavior |
| D001519 | Behavior |
| D000068356 | Self-Control |
| D012919 | Social Behavior |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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