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| ID | Type | Description | Link |
|---|---|---|---|
| 2024-2G-20112 | Other Grant/Funding Number | Capital's Funds for Health Improvement and Research |
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| Name | Class |
|---|---|
| Beijing Municipal Health Commission | OTHER_GOV |
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The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for disability and cognitive impairment among community-dwelling adults aged 65 years and over. The main question it aims to answer is:
BLINDSCE is a community-based prospective cohort study that includes individuals aged 65 and over from urban and rural areas in Beijing. Participants will provide detailed demographic information and undergo multifactorial questionnaires, disability measurements, cognitive assessments, other disability-related outcomes, and clinical biochemical measures. The study has started recruitment and enrollment in 2023 and will follow-up once every 1-2 year. This work consists of three steps as follows. First, by collecting baseline and follow-up data of participants, we plan to establish a community-dwelling elderly database in Beijing. Second, high-risk factors can be pre-screening based on this cross-sectional analysis. Third, longitudinal data was used to develop the prediction model and trajectory analysis for disability and cognitive impairment.
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| Measure | Description | Time Frame |
|---|---|---|
| Disability from the individual's perspective | Disability is assessed using the 12-item World Health Organization's Disability Assessment Schedule 2.0 (WHODAS 2.0). The WHODAS 2.0 is a patient-reported disability measure, comprising six life domains involving cognition, mobility, self-care, interpersonal relationships, life activities, and participation. The total score of 12-item WHODAS 2.0 categorizes disability from no disability (score 0) to complete disability (score 48). | An average of 1 to 2 years |
| Disability from the medical's perspective | Disability is assessed using the basic activities of daily living (BADL) scale, the Katz Index scale. The minimum value is 0 , and the maximum value is 6. The higher the score, the better the outcome. | An average of 1 to 2 years |
| Disability from the medical's perspective | Disability is assessed using the instrumental activities of daily living (IADL) scale, the Lawton and Brody IADL scale. The minimum value is 0, and the maximum value is 8. The higher the score, the better the outcome. | An average of 1 to 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive impairment | The cognitive impairment is assessed by the Mini-Mental State Examination (MMSE). The minimum value is 0, and the maximum value is 30. The higher the score, the better the outcome. | An average of 1 to 2 years |
| Cognitive impairment |
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Inclusion Criteria:
Exclusion Criteria:
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Community residents aged 65 years or older in Beijing
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yansu Guo, Ph.D | Contact | 0086031183973736 | gys188@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yansu Guo, Ph.D | Beijing Geriatric Healthcare and Disease Prevention Center, Xuanwu Hospital, Capital Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xuanwu Hospital, Capital Medical University | Recruiting | Beijing | 100053 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40379348 | Derived | Cheng S, Du X, Hou C, Liu H, Lei S, Wu Y, Yue X, Guo Y. Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE): protocol for a community-based prospective longitudinal cohort study about disability prediction model. BMJ Open. 2025 May 15;15(5):e091955. doi: 10.1136/bmjopen-2024-091955. |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D010335 | Pathologic Processes |
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Plan to obtain blood samples from some of the participants
The cognitive impairment is assessed by the Montreal Cognitive Assessment-Basic (MoCA-B). The minimum value is 0, and the maximum value is 30. The higher the score, the better the outcome. |
| An average of 1 to 2 years |
| Subjective cognitive decline | Subjective cognitive decline is assessed by the subjective cognitive decline questionnaire-9 items (SCD9). The minimum value of SCD9 is 0, and the maximum value is 9, the higher the score, the worse the outcome. | An average of 1 to 2 years |
| Intrinsic capacity | Intrinsic capacity is the composite of physical and mental abilities that an individual can draw upon. It comprises locomotor, sensory (hearing and vision), vitality, psychological, and cognition domains. The intrinsic capacity composite score is used to assess intrinsic capacity. The intrinsic capacity composite score ranges from 0 to 100, and the higher the score, the better the outcome. | An average of 1 to 2 years |
| Intrinsic capacity | Intrinsic capacity is assessed by the integrated care for older people (ICOPE) scale. The minimum value of the ICOPE score is 0, and the maximum value is 5, the higher the score, the better the outcome. | An average of 1 to 2 years |
| Frailty | Frailty is assessed using the Fried frailty phenotype (FFP) scale. The minimum value is 0, and the maximum value is 5. The higher the score, the worse the outcome. | An average of 1 to 2 years |
| Hospitalization | Hospitalized times, duration, diagnosis, surgery, bedridden status, assisted ventilation treatment, catheter treatment are collected by questionnaire and supplemented through a review of electronic medical records. | An average of 1 to 2 years |
| Death | The date and cause of death are collected from the participant's family members/healthcare providers and supplemented through a review of electronic medical records. | An average of 1 to 2 years |
| Appendicular skeletal muscle mass | Appendicular skeletal muscle mass (ASM) is estimated using a physical measurement formula. Weight in kilograms, height in centimeters, gender(male or female), and age in years are combined to report ASM through the formula: ASM = 0.193*weight(kg) + 0.107*height(cm) - 4.157 * gender - 0.037*age(year) - 2.631. The higher the value, the better the outcome. | An average of 1 to 2 years |
| Muscle strength | Muscle strength is assessed by the grip strength. The higher the value, the better the outcome. | An average of 1 to 2 years |
| Physical performance | Physical performance is assessed by the Short Physical Performance Battery (SPPB) test. The minimum score is 0, and the maximum score is 12. The higher the score, the better the outcome. | An average of 1 to 2 years |
| Sarcopenia | Sarcopenia is screened by the SARC-F scale. The minimum value is 0, and the maximum value is 10. The higher the score, the worse the outcome. | An average of 1 to 2 years |
| Sarcopenia | Sarcopenia is assessed based on the criteria recommended by the Asian Working Group for Sarcopenia (AWGS) 2019 consensus, including muscle strength, plus appendicular skeletal muscle mass (ASM), and/or physical performance. AWGS 2019 contends that diagnosing sarcopenia requires both low muscle strength and muscle mass, and defines persons with low muscle mass, low muscle strength, and low physical performance as having "severe sarcopenia." | An average of 1 to 2 years |
| D013568 |
| Pathological Conditions, Signs and Symptoms |