Safety of Short-course of NSAIDs in Pediatric Patients With CKD

Safety of Short-term NSAID Use in the Postoperative Setting in Pediatric Patients With Chronic Kidney Disease

The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This is currently in the process of developing multi institution collaboration within a Pediatric Urology population, intended to inform future work in a larger patient population.

Inclusion Criteria:

• Patients over 18 months of age
• diagnosis of CKD stages 2-3a, confirmed by CKiD U25 eGFR calculator based on cystatin C laboratory testing within 6 months of surgery
• Patient is scheduled to undergo a urologic surgery requiring admission or overnight stay in the hospital

Exclusion Criteria:

• Diagnosis of CKD stage 1 or 4-5
• Past medical history of renal transplant
• Past medical history of nasal polyp
• Procedure for oncologic indications or on chemotherapy
• Pregnant patient
• True allergy to NSAIDs