IMPact of AerobiC Exercise in Addition to Nutritional Treatment on Quality of Life After Pancreatectomy

IMpact of a Program of AerobiC Physical Exercise and Nutritional Therapy, on Quality of Life and Glycometabolic Compensation in Patients Undergoing Pancreatectomy

The goal of this interventional study is to assess the impact of a 6-month unsupervised aerobic exercise program on the quality of life of patients undergoing partial or total pancreatectomy. The main question it aims to answer is:

Does an aerobic exercise program improve physical functioning and overall quality of life in post-pancreatectomy patients?

Eligible participants will be assigned to either an exercise group or a control group. Quality of life will be evaluated using standardized scoring scales, with a focus on physical functioning. Secondary outcomes include changes in metabolic parameters (glycemia, HbA1c, lipid profile), BMI, and overall survival.

Inclusion Criteria:

• Signed informed consent
• Male or female patients who have undergone partial or total pancreatectomy
• Age ≥18 and ≤80 years
• Ability to understand and complete questionnaires and willingness to participate in periodic assessments
• No symptoms suggestive of cardiovascular issues (e.g., angina, dyspnea, palpitations, syncope)
• No evidence of ischemic heart disease, cardiomyopathy, valvular heart disease, myocarditis, autoimmune diseases, infections, or fractures that would contraindicate moderate-intensity aerobic activity

Exclusion Criteria:

• Age >80 or <18 years
• Cardiovascular, musculoskeletal, rheumatologic, or neurocognitive disorders contraindicating aerobic exercise
• 10-year cardiovascular risk >20% without cardiological/sports medicine evaluation
• Diagnosis of unresectable tumor
• Presence of metastases
• Pregnancy or breastfeeding
• Ongoing chemotherapy and/or radiotherapy
• BMI ≥30
• BMI ≤18.5