Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Stanford University | OTHER |
| Peer Support Community Partners | UNKNOWN |
Not provided
Not provided
Not provided
The United States is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief. Those bereaved by overdose experience a unique form of grief characterized by feelings of guilt, shame, and blame, which can worsen their suffering and deter them from seeking help. Individuals coping with overdose loss often endure more severe health consequences compared to those grieving non-drug related deaths, including prolonged grief disorder, substance use disorders, PTSD, depression, and suicidal thoughts. Moreover, bereaved individuals, particularly those with a history of substance use, may engage in risky behaviors as a means of coping, further exacerbating the risk of overdose and mortality within this vulnerable population. Peer grief support interventions have emerged as a promising approach to assist those experiencing such losses. To combat these outcomes, we are collaborating with Peer Community Support Partners (PSCP) in a novel practice-research partnership to implement the RIVER peer grief support model. Though RIVER has shown success in community settings, it has yet to be rigorously evaluated. In a three-aim approach, this study aims to assess the effectiveness of the RIVER model while also enhancing and engaging grievers with support resources via medical examiner offices (MEOs), which routinely contact families during death investigations. This research represents a pivotal advancement in addressing the needs of the overlooked bereaved community, aligning with the NIH's Helping to End Addiction Long-term (HEAL) initiative to develop effective strategies against the opioid crisis. Together, community engagement and rigorous research efforts aim to enhance support for those affected by the tragedy of drug overdose.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peer grief support + enhanced care as usual | Experimental | Participants in this arm will be matched with a peer grief support specialist who will provide support that aligns with the RIVER process model developed by Peer Community Support Partners. They will also receive a psychoeducational booklet and a list of local grief support resources (i.e., the enhanced care as usual condition). |
|
| Enhanced care as usual | Active Comparator | Participants will receive a psychoeducational booklet and a list of local grief support resources. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RIVER | Behavioral | RIVER is a peer grief support process intervention developed by Peer Support Community Partners. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Participant Grief Symptoms | Brief Grief Questionnaire; evaluates the presence of prolonged grief | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Participant Avoidance of Grief Reminders | Grief-Related Avoidance Questionnaire (GRAQ); evaluating the presence and extent of avoidance behaviors due to feelings of grief | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Participant Bereavement Coping Strategies | Coping Assessment for Bereavement (CABLE); evaluating what coping strategies are being utilized and at what frequency | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Participant Acceptance of the Loss | Typical Beliefs Questionnaire (TBQ); evaluating the presence of maladaptive cognitions related to complicated grief | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Participant Perceived Connectedness | Continuing Bonds Scale; assessing the extent to which the participant feels bonded to the descendent | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Participant Substance Use | Tobacco, Alcohol, Prescription Medications, and Other Substances Tool (TAPS); assessing the presence and frequency of past 30-day substance use | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Participant Depression Severity |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alison Athey, PhD | Contact | (703) 413-1100 | 5680 | aathey@rand.org |
| Karen Osilla, PhD | Contact | kosilla@stanford.edu |
| Name | Affiliation | Role |
|---|---|---|
| Alison Athey, PhD | RAND | Principal Investigator |
| Karen Osilla, PhD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jefferson County Coroner/Medical Examiner's Office | Recruiting | Birmingham | Alabama | 35203 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41668117 | Derived | Osilla KC, Watkins KE, Lord T, Lord G, Cook F, Nameth K, Kim JP, Hawkins W, Athey A. Study protocol for a randomized trial examining a peer grief support approach for people grieving drug overdose deaths. Addict Sci Clin Pract. 2026 Feb 11;21(1):24. doi: 10.1186/s13722-026-00652-8. | |
| 40894007 | Derived | Osilla KC, Watkins KE, Lord T, Lord G, Cook F, Nameth K, Kim JP, Hawkins W, Athey A. Study protocol for a randomized trial examining a peer grief support approach for people grieving drug overdose deaths. Res Sq [Preprint]. 2025 Aug 21:rs.3.rs-6959900. doi: 10.21203/rs.3.rs-6959900/v1. |
Not provided
Not provided
Data will be shared by following NIH HEAL Data Sharing Policies.
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000090382 | Prolonged Grief Disorder |
| D019966 | Substance-Related Disorders |
| D062787 | Drug Overdose |
| ID | Term |
|---|---|
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
| D064419 | Chemically-Induced Disorders |
| D063487 | Prescription Drug Misuse |
Not provided
Not provided
| ID | Term |
|---|---|
| D045483 | Rivers |
| ID | Term |
|---|---|
| D055593 | Geological Phenomena |
| D055585 | Physical Phenomena |
| D005618 | Fresh Water |
| D004777 | Environment |
Not provided
Not provided
We will conduct a randomized controlled trial (RCT) of peer grief support plus enhanced care as usual vs. enhanced care as usual only (i.e., parallel interventional study model).
Not provided
Not provided
Not provided
| Enhanced care as usual | Behavioral | The enhanced care as usual condition involves a psychoeducational booklet developed by What's Your Grief, as well as a list of local grief resources. |
|
Beck Depression Inventory (BDI); evaluating the presence and severity of depressive symptoms |
| Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Participant Posttraumatic Stress Symptoms | Posttraumatic Stress Disorder Checklist (PCL-5); evaluating the severity of symptoms associated with posttraumatic stress disorder | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| Participant Physical Pain Severity | PEG; evaluating the intensity and interference of physical pain on daily life and well-being | Baseline, 3-month follow up, 6-month follow up, and 12-month follow up |
| San Diego County Medical Examiner Office | Recruiting | San Diego | California | 92123 | United States |
|
| Connecticut Office of the Chief Medical Examiner | Recruiting | Farmington | Connecticut | 06032 | United States |
|
| Peer Support Community Partners | Active, not recruiting | Watertown | Massachusetts | 02472 | United States |
| D000076064 | Drug Misuse |
| D055669 |
| Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |
| D004778 | Environment and Public Health |