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This study intends to use MRI technology to analyze the dynamic changes and microstructure changes of the brain network in patients with trigeminal neuralgia, evaluate the blood-brain barrier and water exchange rate, and further analyze their correlation with clinical indicators, so as to explore the changes in brain structural plasticity and potential neural mechanisms
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Trigeminal Neuralgia Group | Patients who were diagnosed with trigeminal neuralgia (TN) according to the International Classification of Headache Disorders (ICHD) and were intolerant or ineffective to the preoperative treatment of carbamazepine or ocasepine, requiring the treatment of percutaneous balloon compression (PBC) | ||
| Health Control Group | Healthy controls matched by age, sex, etc |
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| Measure | Description | Time Frame |
|---|---|---|
| Scanning sequence of magnetic resonance imaging (MRI) | such as 3D-T1, 3D-T2, BOLD-functional MRI (fMRI), diffusion weighted imaging (DWI) (Multiple b values, such as 0,1000,2000), diffusion-prepared, arterial spin labeling (DP-ASL), Meningeal lymphatic sequence (3D T2-FLAIR ). | Preoperative routine MRI examination |
| Measure | Description | Time Frame |
|---|---|---|
| Brief Pain Inventory (BPI) | The BPI is divided into two parts, one of which assesses pain severity on a scale of 0 to 10, where 0 means "no pain" and 10 means "most severe pain." The other assessed the extent to which pain interfered with daily activities, including seven areas of general activity, mood, ability to walk, normal work (including housework), relationships, sleep, and enjoyment of life, with 0 being "no impact" and 10 being "significant impact." |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with TN undergoing PBC and healthy controls matched by age and sex.
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| ID | Term |
|---|---|
| D014277 | Trigeminal Neuralgia |
| ID | Term |
|---|---|
| D020433 | Trigeminal Nerve Diseases |
| D005156 | Facial Neuralgia |
| D005155 | Facial Nerve Diseases |
| D009059 | Mouth Diseases |
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| Baseline, until to discharge (an average of 3 days), 3 months after surgery |
| Simplified McGill pain questionnaire (SF-MPQ) | The scale consisted of two subscales with 11 pain description items and 4 emotional assessment items [pain-free (0), mild (1), moderate (2), severe (3)], and a visual analog scale (VAS) [0-10, painless (0), severe pain (10)] was added to assess pain intensity. | Baseline, 3 months after surgery |
| Douleur Neuropathique 4 Questions (DN4) | The scale contains 10 items, divided into two parts: Symptom description (7 items) : covers burning pain, cold pain, electric shock pain, tingling pain, acupuncture pain, numbness, and pruritus. Clinical examination (3 items) : Includes loss of touch, loss of tingling, and whether rubbing in the pain area induces or worsens pain. "Yes" scores 1 point for each item, "no" scores 0 points, total score ≥4 points can be diagnosed as neuropathic pain | Baseline, 3 months after surgery |
| Beck Depression Inventory (BDI) | BDI consists of 21 items, each corresponding to a common depressive symptom, such as sadness, insomnia, fatigue and feelings of worthlessness. Each item has four options, representing the severity of symptoms, on a scale of 0 (no symptoms) to 3 (severe symptoms). The overall score ranges from 0 to 63, with the higher the score, the more severe the depressive symptoms. | Baseline, 3 months after surgery |
| Beck Anxiety Inventory (BPI) | BAI consists of 21 items, each describing an anxiety-related symptom, and subjects are required to choose the answer that best fits their situation based on their feelings in the past week. A 4-level scoring method was adopted: 0: None
| Baseline, 3 months after surgery |
| Pittsburgh Sleep Quality Index (PSQI) | The PSQI contains 19 self-rated entries and 5 other rated entries, but only 19 self-rated entries participate in the score. The entries are divided into seven components, each scored on a 0-3 scale, with an overall score ranging from 0-21. | Baseline, 3 months after surgery |
| Blood immune inflammation indicators | such as interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), C-reactive protein (CRP), calcitonin gene-related peptide (CGRP), neurofilament light chain (sNfL), glial fibrillary acidic protein (sGFAP). | Baseline |
| PBC asscoated adverse reactions | such as hypoesthesia (numbness of the face and tongue), decreased corneal reflexes, dry eye, double vision, masseter weakness, oral herpes simplex | 24 hours after surgery, 3 months after surgery |
| D009057 |
| Stomatognathic Diseases |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |