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The goal of this clinical trial is to learn the efficacy and safety of tislelizumab in combination with chemotherapy(etoposide/cisplatin ) ± concurrent radiotherapy for extensive-stage oligometastatic small cell lung cancer. 64 Patients with Extensive-Stage Oligometastatic Small Cell Lung Cancer will be randomly divided into the experimental group (tislelizumab combined with chemotherapy and radiotherapy) and the control group (tislelizumab combined with chemotherapy).Researchers will compare treatment efficacy and safety between the two groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| experimental group | Experimental | Chemotherapy and tislelizumab with Concurrent Chest Radiotherapy or Radiotherapy for oligometastases |
|
| placebo group | Placebo Comparator | Chemotherapy and tislelizumab with no radiotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| radiotherapy | Radiation | Palliative radiotherapy for oligometastases can be combined with chemoradiotherapy and immunomaintenance therapy period. The investigator determines the number, timing and regimen of oligometastases according to the location, size, symptoms and patient tolerance of oligometastases |
| Measure | Description | Time Frame |
|---|---|---|
| Progression free survival | Progression free survival | 2years |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Overall survival | 2years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wenbin Shen | Contact | 8615831183879 | wbshen2024@hebmu.edu.cn | |
| Xuehan Guo | Contact | 8613833156327 | 448707059@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hebei Medical University Fourth Hospital | Shijiazhuang | Hebei | 050000 | China |
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|
| immunechemotherapy | Drug | Tislelizumab in Combination With Chemotherapy(etoposide/cisplatin ) |
|
| ID | Term |
|---|---|
| D011878 | Radiotherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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