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The purpose of this study is to investigate if different emotional states could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain - related negative affect in individuals with chronic pain.
Participants with chronic pain will be randomized into 4 different groups watching different short video-clips (2.20 min), while at the same time experience short-lasting, experimentally induced pain. The negative emotions group will watch an uncomfortable short video containing violence and blood, the positive emotions group will watch a video containing a stand-up comedy show, the neutral emotions group will watch a video about how to paint a house, and the control group will just wait for 2.20 min, without any instructions about what to think about. Pressure pain thresholds, pain tolerance, pain intensity and pain-related negative affect will be measured with an algometer before and after the video-clip combined with experimental pain interventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: Negative emotion, positive emotion, neutral emotion, control with experimental pain | Experimental | Arm Description: The intervention includes either a negatively emotionally valenced video, a positively emotionally valenced video, a neutrally emotionally valenced video and experimental pain from the cold pressor test that are simultaneosly applied. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Emotional intervention | Other | Emotional intervention Description: The participant will watch a short video-clip with negative emotional content while simultaneously experience experimentally induced pain. |
| Measure | Description | Time Frame |
|---|---|---|
| Pressure pain thresholds | Description: Pressure pain thresholds will be measured i kPa with a handheld algometer (Somedic AB). | Day 1: baseline PPTs are measured, intervention 2.20 min follows and intervention PPTs are measured directly after the intervention. Recruitment for single appointments for each participant will take place for 4 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain tolerance (time in seconds the left hand is immersed in cold water 1 degree C). | Description: The measure pain tolerance equals the time the time the participant keeps their left hand immersed in cold water (1 degree C), before they decide to withdraw their hand. This will be measured in seconds. For each participant, the maximum time to keep the hand immersed in water is 300 seconds. Participants are successively recruited for single appointments for 4 months. |
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Inclusion Criteria:
Exclusion criteria:
- Known neurological disease
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Helena Gunnarsson, Dr | Contact | +46708432509 | helena.gunnarsson@lnu.se |
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Within-subjects design
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| Emotional intervention | Other | Description: The participant will watch a short video-clip with positive emotional content while simultaneously experience experimentally induced pain. |
|
| Emotional intervention | Other | Description: The participant will watch a short video-clip with neutral emotional content while simultaneously experience experimentally induced pain. |
|
| Day 1: During a single session (30 min), the participant will keep their hand immersed in cold water for as long as possible while watching a video. This time will be measured in seconds. |
| Pain intensity on the NRS | Participants will rate their perceived pain intensity on the NRS (Numerical Rating Scale) after the intervention (film-clip combined with pain induction using the cold pressor apparatus with cold water 1 degree C. This will take place on a single session appointment for each participant. Participants will be successively recruited for single session appointments for 4 months. | Day 1: Pain intensity will be estimated at single session appointments (30 min) on the NRS (Numerical Rating Scale) after the intervention. Participants will be successively recruited for single session appointments for 4 months. |
| Pain-related negative affect on the NRS-A | Description: Perceived pain-related negative affect will be estimated on the NRS-A (Numerical Rating Scale- Anxiety) after the intervention (film-clip combined with pain induction with the cold pressor apparatus with cold water 1 degree C).The pain intensity will be estimated at every single session appointment (30 min) after the intervention on the NRS (Numerical Rating Scale). The participants will be successively recruited for single session appointments for 4 months. | Day 1: Pain intensity will be estimated at single session appointments (30 min) on the NRS-A (Numerical Rating Scale-Anxiety) after the intervention. Participants will be successively recruited for single session appointments for 4 months. |
| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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