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This study is to evaluate the effects of dexmedetomidine and magnesium sulfate on cerebral oxygen saturation in patients undergoing spine surgeries as adjuvant to general anesthesia guided by cerebral oximetry. The main aims to are Incidence of cerebral desaturation events and duration of cerebral desaturation events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MgSO4 | Active Comparator | loading dose of 40 mg/kg of magnesium sulfate diluted in 50 ml of 0.9% saline IVI will be given in 10 min before anesthesia induction then continuous infusion of 10 mg/kg/hour during the surgery. |
|
| dex. | Active Comparator | Patients will receive loading dose of 1 mcg/kg dexmedetomidine diluted in 50 ml of saline 0.9% IVI will be given in 10 min before anesthesia induction then continuous infusion of 0.5 mcg/kg/hour during the surgery. |
|
| control | Placebo Comparator | Patients will receive the same volume of normal saline. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| spine surgery | Procedure | spine surgery in prone position |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of cerebral desaturation events. | intraoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of cerebral desaturation events | intraoperative | |
| change in heart rate in beats | intraoperative | |
| change in blood pressure in mmHg |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ibrahim Elsayed Elnefiawy, assisstant lectuerer | Contact | 00201001515007 | aborazan171@gmail.com | |
| Nadia Elsayed Elafify, assistant lectuerer | Contact | 0020110627640 | nadiaelsayed225@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ahmed Said Elgebaly, professor | Tanta University | Study Director |
| Shimaa Farouk Abdelkader, professor | Tanta University | Study Director |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| D020927 | Dexmedetomidine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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| Magnesium sulfate | Drug | Patients will receive loading dose of 40 mg/kg of magnesium sulfate diluted in 50 ml of 0.9% saline IVI will be given in 10 min before anesthesia induction then continuous infusion of 10 mg/kg/hour during the surgery. |
|
| Dexmedetomidine | Drug | Patients will receive loading dose of 1 mcg/kg dexmedetomidine diluted in 50 ml of saline 0.9% IVI will be given in 10 min before anesthesia induction then continuous infusion of 0.5 mcg/kg/hour during the surgery. |
|
| Normal Saline (0.9% NaCl) | Drug | Patients will receive the same volume of normal saline. |
|
| Intraoperative |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |