Mg Sulfate Versus Dexmedetomidine on Cerebral Oxygen Saturation

Effects of Dexmedetomidine Versus Magnesium Sulfate on Cerebral Oxygen Saturation During Spine Surgery: a Prospective Randomized Controlled Study

This study is to evaluate the effects of dexmedetomidine and magnesium sulfate on cerebral oxygen saturation in patients undergoing spine surgeries as adjuvant to general anesthesia guided by cerebral oximetry. The main aims to are Incidence of cerebral desaturation events and duration of cerebral desaturation events.

Inclusion Criteria:

• Age from 21 to 60 years old.
• either gender.
• American Society of Anesthesiologists (ASA) physical status I and II.

Exclusion Criteria:

• Patient refusal to participate in research.
• History of preoperative neuromuscular disease.
• Patients with preexisting cerebral pathology (such as previous episodes of cerebral ischemia or stroke).
• History of psychiatric illness.
• History of orthostatic hypotension, myocardial infarction, uncontrolled hypertension or documented carotid stenosis.
• Coagulopathy disorder.
• Patients receiving magnesium supplementation.
• Chronic use of opioids.
• Current treatment with a β-blocker or calcium channel blocker.