Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes

Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes in Healthy Older Adults and People With Mild Cognitive Impairment

The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level. Previous studies found that exercise can prevent executive and physical dysfunctions for people with MCI. However, the motivation is a critical factor in supporting a sustainable exercise. Exergame is combination of exercise and video game. Enjoyment during playing an exergame can support the exercise motivation. Therefore, we will explore the feasibility of using MR exergame in people with MCI.

Inclusion Criteria

• Healthy group: 1) MoCA score > 24; 2) Independent walking without using gait aids; 3) No diagnosis of the dementia by clinician.
• MCI group: 1) MoCA score between 16 to 24; 2) Independent walking without using gait aids.

Exclusion Criteria:

• Uncontrolled high blood pressure (more than 140/90 mmHg)
• Hemodialysis
• Have clinical diagnosis of the disease or symptoms that could influence the performance assessments such as arthritis or severe hand pain which reports by participants and the testing by physiotherapist before testing.
• History of neurological disorder, such as stroke or other neurodegenerative disorder
• Taking medicine which affected to functional movement.
• Unable to follow study protocol.
• Uncorrected visual or hearing impairment.
• Positive screening for contraindication of TMS which will be confirmed by TMS screening questionnaire such as uncontrolled seizures.