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Pancreatic adenocarcinoma is the most pessimistic digestive cancer in terms of prognosis. Tumor response assessment is crucial, and the recent development of new magnetic resonance imaging sequences, such as high resolution applied to diffusion sequences (Harder et al., 2022) or magnetic resonance elastography (MRE) (Steinkohl et al., 2021), could help address this issue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient with a resectable pancreatic lesion | Experimental | Pancreatic resection surgery |
|
| Patient with a borderline pancreatic lesion | Experimental | Potential pancreatic resection surgery after chemotherapy. |
|
| Patient with locally advanced pancreatic lesion. | Experimental | Chemotherapy treatment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic resonance elastography (MRE). | Device | Magnetic resonance elastography (MRE) is an imaging technique that measures tissue stiffness by assessing the deformation waves produced under external pressure |
| Measure | Description | Time Frame |
|---|---|---|
| Absolute elasticity value of the tumor (kPa) before treatment. | The absolute elasticity value of the tumor corresponds to the average elasticity value measured within the region of interest, which will be outlined according to the tumor's boundaries. | Baseline (J0) before treatment |
| Absolute elasticity value of the tumor (kPa) after chemotherapy. | The absolute elasticity value of the tumor corresponds to the average elasticity value measured within the region of interest, which will be outlined according to the tumor's boundaries. | 3 months, after chimiotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| For patient with a resectable pancreatic lesion, evaluation of the association between size of the tumor (mm) with the absolute elasticity value of the tumor (kPa). | 3 months, after surgery | |
| For the patients who underwent surgery, evaluation of the association between size of the tumor (mm) and the absolute elasticity value of the tumor (kPa) before chimiotherapy. |
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Inclusion Criteria:
Exclusion Criteria:
Patient with a contraindication to MRI.
Person referred to in Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the French Public Health Code.
Person deprived of liberty by a judicial or administrative decision, or person undergoing psychiatric care pursuant to Articles L. 32-12-1 and L. 3213-1 of the French Public Health Code.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guillaume DROUOT, PhD | Contact | 0385157666 | +33 | g.drouot@chru-nancy.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Nancy | Recruiting | Vandœuvre-lès-Nancy | France | 54511 | France |
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| High-resolution diffusion sequence in MRI | Device | High-resolution diffusion sequence in MRI is an imaging technique that uses the movement of water molecules within tissues to generate detailed images. |
|
| 6 months, after surgery |
| For the patients who underwent surgery, evaluation of the association between size of the tumor (mm) and the absolute elasticity value of the tumor (kPa) after chimiotherapy.. | 6 months, after surgery |
| For patient with a resectable pancreatic lesion, evaluation of the association between size of the tumor (mm) with the apparent coefficient diffusion (ADC) in mm²/s. | 3 months, after surgery |
| For the patients who underwent surgery, evaluation of the association between size of the tumor (mm) with the apparent coefficient diffusion (ADC) in mm²/s before chimiotherapy.. | 6 months, after surgery |
| For the patients who underwent surgery, evaluation of the association between size of the tumor (mm) and the apparent coefficient diffusion (ADC) in mm²/s after chimiotherapy.. | 6 months, after surgery |
| Overall survival in years | Time interval between the inclusion date and the date of death from any cause. | At the end of the follow-up period (maximum 24 months). |
| ID | Term |
|---|---|
| D054459 | Elasticity Imaging Techniques |
| ID | Term |
|---|---|
| D014463 | Ultrasonography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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