A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With... | NCT06841354 | Trialant

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With... | NCT06841354 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

Has locally recurrent unresectable or metastatic TNBC that cannot be treated with curative intent

Has not received systemic treatment for locally recurrent unresectable or metastatic breast cancer

Participants previously treated for early-stage breast cancer must have completed all prior therapy for early-stage breast cancer with curative intent at least 6 months before the first disease recurrence

Is a candidate for treatment with pembrolizumab and one of the TPC options: paclitaxel or nab-paclitaxel or gemcitabine + carboplatin

Participants who have AEs due to previous anticancer therapies must have recovered to ≤Grade 1 or baseline with the exception of alopecia or vitiligo. Participants with endocrine-related AEs who are adequately treated with hormone replacement are eligible

Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load

Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

Has breast cancer amenable to treatment with curative intent

Has TNBC with evaluable tumor programmed death ligand 1 (PD-L1) expression at combined positive score (CPS) ≥10

Has received prior systemic therapy for treatment of locally recurrent unresectable or metastatic breast cancer

Has Grade ≥2 peripheral neuropathy

Has history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing

Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease

Has uncontrolled, significant cardiovascular disease or cerebrovascular disease

Has skin only metastatic disease

Has advanced/metastatic, symptomatic visceral spread at risk of rapidly evolving into life-threatening complications

Human immunodeficiency virus (HIV)-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease

Has known additional malignancy that is progressing or has required active treatment within the past 5 years

Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are radiologically stable

Active autoimmune disease that has required systemic treatment in the past 2 years. Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid) is allowed

Has a history of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids, has current pneumonitis/ILD, or has suspected ILD or pneumonitis that cannot be ruled out by standard diagnostic assessments

Concurrent active Hepatitis B (defined as HBsAg positive and/or detectable HBV deoxyribonucleic acid (DNA)) and Hepatitis C virus (HCV) (defined as anti-HCV antibody (Ab) positive and detectable HCV ribonucleic acid (RNA)) infection

History of stem cell/solid organ transplant

Has not adequately recovered from major surgery or has ongoing surgical complications

USA Mitchell Cancer Institute ( Site 0090)Recruiting

Mobile, Alabama 36604, United States

Study CoordinatorContact

251-410-4924

Ironwood Cancer & Research Centers ( Site 0036)Recruiting

Chandler, Arizona 85224, United States

City of Hope ( Site 0097)Recruiting

Duarte, California 91010, United States

City of Hope Lennar Foundation Cancer Center ( Site 0099)Recruiting

Irvine, California 92618, United States

UCLA Department of Medicine - Hematology & Oncology ( Site 0047)Recruiting

Los Angeles, California 90095, United States

UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0016)Recruiting

San Francisco, California 94158, United States

Yale New Haven Hospital ( Site 0001)Completed

New Haven, Connecticut 06520, United States

Washington Hospital Center ( Site 0098)Recruiting

Washington D.C., District of Columbia 20010-2975, United States

AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0007)Recruiting

Altamonte Springs, Florida 32701, United States

Orlando Health Cancer Institute ( Site 0012)Recruiting

Orlando, Florida 32806, United States

Florida Cancer Specialists - East ( Site 7000)Recruiting

West Palm Beach, Florida 33401, United States

University Cancer & Blood Center, LLC ( Site 0023)Recruiting

Athens, Georgia 30607, United States

St. Luke's Cancer Institute: Boise ( Site 0037)Recruiting

Boise, Idaho 83712, United States

University of Illinois Cancer Center ( Site 0044)Recruiting

Chicago, Illinois 60612, United States

MedStar Franklin Square Medical Center ( Site 0031)Recruiting

Baltimore, Maryland 21237, United States

MedStar Good Samaritan Hospital ( Site 0079)Recruiting

Baltimore, Maryland 21239, United States

MedStar Southern Maryland Hospital Center ( Site 0100)Recruiting

Clinton, Maryland 20735, United States

MedStar Montgomery Medical Center ( Site 0078)Recruiting

Olney, Maryland 20832, United States

Holy Cross Hospital ( Site 0091)Recruiting

Silver Spring, Maryland 20910, United States

Cancer & Hematology Centers of Western Michigan ( Site 0026)Recruiting

Grand Rapids, Michigan 49503, United States

Allina Health Cancer Institute ( Site 0069)Recruiting

Minneapolis, Minnesota 55407, United States

Hattiesburg Clinic Hematology/Oncology ( Site 0104)Recruiting

Hattiesburg, Mississippi 39401, United States

Comprehensive Cancer Centers of Nevada ( Site 0015)Recruiting

Las Vegas, Nevada 89106, United States

Renown Regional Medical Center ( Site 0005)Recruiting

Reno, Nevada 89502, United States

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0082)Recruiting

Hackensack, New Jersey 07601, United States

New Mexico Oncology Hematology Consultants Ltd. ( Site 0019)Recruiting

Albuquerque, New Mexico 87109, United States

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0073)Recruiting

Mineola, New York 11501, United States

Laura and Isaac Perlmutter Cancer Center ( Site 0003)Recruiting

New York, New York 10016, United States

Rex Hematology Oncology Associates - Garner ( Site 0071)Completed

Garner, North Carolina 27529, United States

SCRI Oncology Partners ( Site 7004)Recruiting

Nashville, Tennessee 37203, United States

Tennessee Oncology ( Site 0018)Recruiting

Nashville, Tennessee 37203, United States

Texas Oncology - DFW ( Site 8007)Recruiting

Dallas, Texas 75231, United States

Texas Oncology - West Texas ( Site 8004)Recruiting

El Paso, Texas 79902, United States

Kelsey-Seybold Clinic - North Houston Campus ( Site 0096)Recruiting

Houston, Texas 77014, United States

Kelsey-Seybold Clinic ( Site 0040)Recruiting

Houston, Texas 77025, United States

Texas Oncology - San Antonio ( Site 8001)Recruiting

San Antonio, Texas 78240, United States

University of Utah, Huntsman Cancer Institute ( Site 0056)Recruiting

Salt Lake City, Utah 84112, United States

Virginia Oncology Associates (VOA) ( Site 8002)Recruiting

Norfolk, Virginia 23502, United States

Fred Hutchinson Cancer Center ( Site 0042)Recruiting

Seattle, Washington 98109, United States

Instituto de Investigaciones Clinicas Mar del Plata ( Site 2401)Recruiting

Mar del Plata, Buenos Aires B7600FZN, Argentina

Instituto Alexander Fleming ( Site 2402)Recruiting

Mar del Plata, Buenos Aires C1426ANZ, Argentina

Hospital Italiano de Cordoba ( Site 2406)Recruiting

Córdoba, Córdoba Province X5004BAL, Argentina

Clinica Viedma ( Site 2403)Recruiting

Viedma, Río Negro Province R8500ACE, Argentina

Fundacion Estudios Clinicos ( Site 2405)Recruiting

Rosario, Santa Fe Province S2000DEJ, Argentina

Hospital Provincial del Centenario ( Site 2410)Recruiting

Rosario, Santa Fe Province S2002KDR, Argentina

Fundacion Centro Oncologico de Integración Regional ( Site 2400)Recruiting

Mendoza, M5500AYB, Argentina

Blacktown Hospital ( Site 5500)Recruiting

Blacktown, New South Wales 2148, Australia

Peninsula Health Frankston Hospital ( Site 5501)Recruiting

Frankston, Victoria 3199, Australia

ZAS Sint Augustinus ( Site 3102)Recruiting

Antwerp, Flanders 2610, Belgium

Ziekenhuis Oost Limburg ( Site 3105)Recruiting

Genk, Limburg 3600, Belgium

AZ Maria Middelares ( Site 3103)Recruiting

Ghent, Oost-Vlaanderen 9000, Belgium

UZ Gent ( Site 3101)Recruiting

Ghent, Oost-Vlaanderen 9000, Belgium

Hospital de Câncer de Recife ( Site 2300)Recruiting

Recife, Pernambuco 50040-000, Brazil

Liga Norte Riograndense Contra o Cancer ( Site 2310)Recruiting

Natal, Rio Grande do Norte 59062-000, Brazil

Hospital Nossa Senhora da Conceição ( Site 2302)Recruiting

Porto Alegre, Rio Grande do Sul 91350-200, Brazil

Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 2307)Recruiting

Barretos, São Paulo 14784-400, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 2301)Recruiting

São Jose Do Rio Preto, São Paulo 15090-000, Brazil

Study CoordinatorContact

+55 (17) 3201-5054

IBCC - Núcleo de Pesquisa e Ensino ( Site 2306)Recruiting

São Paulo, 04014-002, Brazil

Cross Cancer Institute ( Site 0216)Recruiting

Edmonton, Alberta T6G 1Z2, Canada

Lakeridge Health ( Site 0217)Recruiting

Oshawa, Ontario L1G 2B9, Canada

North York General Hospital ( Site 0209)Recruiting

Toronto, Ontario M2K 1E1, Canada

Princess Margaret Cancer Centre ( Site 0202)Recruiting

Toronto, Ontario M5G 2M9, Canada

CIUSSS- saguenay-Lac-Saint-Jean ( Site 0213)Recruiting

Chicoutimi, Quebec G7H 5H6, Canada

Centre Hospitalier de l'Université de Montréal ( Site 0208)Recruiting

Montreal, Quebec H2X 3E4, Canada

Jewish General Hospital ( Site 0203)Recruiting

Montreal, Quebec H3T 1E2, Canada

St. Marys Hospital Center ( Site 0201)Recruiting

Montreal, Quebec H3T 1M5, Canada

McGill University Health Centre ( Site 0204)Recruiting

Montreal, Quebec H4A 3J1, Canada

Hopital Du Saint-Sacrement ( Site 0210)Recruiting

Québec, Quebec G1S 4L8, Canada

Saskatoon Cancer Centre ( Site 0215)Recruiting

Saskatoon, Saskatchewan S7N 4H4, Canada

Biocenter ( Site 2009)Recruiting

Concepción, Biobio 4070196, Chile

IC La Serena Research ( Site 2007)Recruiting

La Serena, Coquimbo Region 1720430, Chile

FALP ( Site 2000)Recruiting

Santiago, Region M. de Santiago 7500921, Chile

Clínica UC San Carlos de Apoquindo ( Site 2008)Recruiting

Santiago, Region M. de Santiago 7620002, Chile

Bradfordhill ( Site 2001)Recruiting

Santiago, Region M. de Santiago 8420383, Chile

ONCOCENTRO APYS ( Site 2005)Recruiting

Viña del Mar, Valparaiso 2520598, Chile

The First Afflilated Hospital of Bengbu Medical College ( Site 5022)Recruiting

Bengbu, Anhui 233004, China

The First Affiliated Hospital of Chongqing Medical University ( Site 5039)Recruiting

Chongqing, Chongqing Municipality 400016, China

Chongqing University Three Gorges Hospital ( Site 5020)Recruiting

Chongqing, Chongqing Municipality 404000, China

The First Affiliated hospital of Xiamen University ( Site 5035)Recruiting

Xiamen, Fujian 361003, China

Sun Yat-Sen University Cancer Center ( Site 5014)Recruiting

Guangzhou, Guangdong 510060, China

Guangxi Medical University Affiliated Tumor Hospital. ( Site 5008)Recruiting

Nanning, Guangxi 530201, China

Henan Cancer Hospital ( Site 5001)Recruiting

Zhengzhou, Henan 450008, China

Tongji Hospital Tongji Medical Science & Technology ( Site 5007)Recruiting

Wuhan, Hubei 430030, China

Xiangyang Central Hospital ( Site 5017)Recruiting

Xiangyang, Hubei 441021, China

Hunan Cancer Hospital ( Site 5002)Recruiting

Changsha, Hunan 410013, China

Jiangsu Province Hospital ( Site 5009)Recruiting

Nanjing, Jiangsu 210029, China

Xuzhou Central Hospital ( Site 5036)Recruiting

Xuzhou, Jiangsu 221009, China

The First Hospital of Jilin University ( Site 5003)Recruiting

Changchun, Jilin 130021, China

The First Affiliated Hospital of Xi an Jiaotong University ( Site 5005)Recruiting

Xi'an, Shaanxi 710061, China

Jinan Central Hospital ( Site 5031)Recruiting

Jinan, Shandong 250013, China

LinYi Cancer Hospital ( Site 5021)Recruiting

Linyi, Shandong 276000, China

Shanxi Cancer Hospital ( Site 5043)Recruiting

Taiyuan, Shanxi 030000, China

Sichuan Cancer Hospital. ( Site 5018)Recruiting

Chengdu, Sichuan 610041, China

The Second People's Hospital of Neijiang ( Site 5016)Recruiting

Neijiang, Sichuan 641099, China

Affiliated Tumor Hospital of Xinjiang Medical University ( Site 5006)Recruiting

Ürümqi, Xinjiang 830011, China

The First Affiliated Hospital Zhejiang University School of Medicine ( Site 5026)Recruiting

Hangzhou, Zhejiang 310003, China

Zhejiang Cancer Hospital ( Site 5012)Recruiting

Hangzhou, Zhejiang 310022, China

The Second Affiliated hospital of Zhejiang University school of medicine ( Site 5024)Recruiting

Hangzhou, Zhejiang 310052, China

Taizhou Hospital of Zhejiang Province ( Site 5029)Recruiting

Linhai, Zhejiang 317000, China

Promotora Médica Las Américas S.A. ( Site 2206)Recruiting

Medellín, Antioquia 050021, Colombia

Centro Cancerologico del Caribe LTD ( Site 2209)Recruiting

Barranquilla, Atlántico 080002, Colombia

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2203)Recruiting

Bogotá, Bogota D.C. 110131, Colombia

IMAT S.A.S ( Site 2202)Active, not recruiting

Montería, Departamento de Córdoba 230002, Colombia

Oncologos Del Occidente ( Site 2208)Recruiting

Pereira, Risaralda Department 660001, Colombia

Fakultni nemocnice Ostrava ( Site 3505)Recruiting

Ostrava - Poruba, Moravian-Silesian Region 708 52, Czechia

Study CoordinatorContact

+420597372124

Vseobecna fakultni nemocnice v Praze ( Site 3501)Recruiting

Prague, Praha 2 128 00, Czechia

Masarykuv onkologicky ustav ( Site 3500)Recruiting

Brno, South Moravian 656 53, Czechia

Fakultni nemocnice Olomouc ( Site 3502)Recruiting

Olomouc, 77900, Czechia

Fakultni Thomayerova nemocnice ( Site 3506)Recruiting

Prague, 140 59, Czechia

Fakultni nemocnice v Motole ( Site 3503)Recruiting

Prague, 150 06, Czechia

Rigshospitalet University Hospital ( Site 3201)Recruiting

Copenhagen, Capital Region 2100, Denmark

Herlev og Gentofte Hospital. ( Site 3205)Recruiting

Copenhagen, Capital Region 2730, Denmark

Aarhus Universitets hospital ( Site 3204)Recruiting

Aarhus, Central Jutland 8200, Denmark

Odense Universitetshospital ( Site 3202)Recruiting

Odense, Region Syddanmark 5000, Denmark

Oulun yliopistollinen sairaala-Oncology and Hematology ( Site 3304)Recruiting

Oulu, North Ostrobothnia 90220, Finland

Tampereen yliopistollinen sairaala-Oncology ( Site 3302)Recruiting

Tampere, Pirkanmaa 33520, Finland

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 3301)Recruiting

Helsinki, Uusimaa 00029, Finland

CENTRE LEON BERARD ( Site 3004)Recruiting

Lyon, Auvergne-Rhône-Alpes 69373, France

Clinique Francois Chenieux ( Site 3006)Recruiting

Limoges, Haute-Vienne 87000, France

Institut Regional du Cancer Montpellier ( Site 3009)Recruiting

Montpellier, Herault 34298, France

Institut De Cancerologie De L Ouest ( Site 3003)Recruiting

Saint-Herblain, Loire-Atlantique 44805, France

Institut Jean Godinot ( Site 3002)Recruiting

Reims, Marne 51100, France

Centre Henri Becquerel ( Site 3001)Recruiting

Rouen, Seine-Maritime 76038, France

HIA Sainte Anne ( Site 3007)Recruiting

Toulon, Var 83800, France

Groupe Hospitalier Paris Saint Joseph ( Site 3010)Recruiting

Paris, 75014, France

Hôpital Européen Georges Pompidou ( Site 3011)Recruiting

Paris, 75015, France

Universitatsklinikum Erlangen ( Site 4302)Recruiting

Erlangen, Bavaria 91054, Germany

Luisenkrankenhaus Düsseldorf ( Site 4305)Completed

Düsseldorf, North Rhine-Westphalia 40235, Germany

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinik für Senologie/ Brustzentrum ( Site 4304)Recruiting

Essen, North Rhine-Westphalia 45136, Germany

Caritas Klinikum Saarbruecken St. Theresia ( Site 4301)Recruiting

Saarbrücken, Saarland 66113, Germany

Universitaetsklinikum Leipzig ( Site 4307)Recruiting

Leipzig, Saxony 04103, Germany

HELIOS Klinikum Berlin-Buch ( Site 4303)Recruiting

Berlin, 13125, Germany

Aretaieio Hospital ( Site 3900)Recruiting

Athens, Attica 115 28, Greece

University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 3903)Recruiting

Heraklion, Irakleio 715 00, Greece

General University Hospital of Larissa, Oncology Clinic ( Site 3902)Recruiting

Larissa, Thessaly 411 10, Greece

European Interbalkan Medical Center ( Site 3901)Recruiting

Thessaloniki, 570 01, Greece

Queen Mary Hospital ( Site 6000)Recruiting

Hong Kong, 000000, Hong Kong

Prince of Wales Hospital ( Site 6001)Recruiting

Hong Kong, Hong Kong

Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház-Megyei Onkológiai Centrum ( Site 3405)Recruiting

Gyula, Bekes County 5700, Hungary

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 3407)Recruiting

Szeged, Csongrád megye 6720, Hungary

Budapesti Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 3408)Recruiting

Budapest, Pest County 1145, Hungary

Study CoordinatorContact

+36 1 467-3700/1245

Semmelweis Egyetem-Belgyógyászati és Onkológiai Klinika ( Site 3404)Recruiting

Budapest, 1082, Hungary

Országos Onkológiai Intézet-B-Belgyógyászati Onkológiai Osztály ( Site 3406)Recruiting

Budapest, 1122, Hungary

Debreceni Egyetem Klinikai Kozpont ( Site 3411)Recruiting

Debrecen, 4032, Hungary

Rambam Health Care Campus ( Site 3700)Recruiting

Haifa, 3109601, Israel

Shaare Zedek Medical Center ( Site 3704)Recruiting

Jerusalem, 9103102, Israel

Rabin Medical Center ( Site 3702)Recruiting

Petah Tikva, 4941492, Israel

Sheba Medical Center ( Site 3701)Recruiting

Ramat Gan, 5265601, Israel

Sourasky Medical Center ( Site 3703)Recruiting

Tel Aviv, 6423906, Israel

Istituto Nazionale Tumori Regina Elena ( Site 4607)Recruiting

Rome, Roma 00128, Italy

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 4605)Recruiting

Bologna, 40138, Italy

Ospedale Policlinico San Martino ( Site 4606)Recruiting

Genova, 16132, Italy

IRCCS Ospedale San Raffaele ( Site 4600)Recruiting

Milan, 20132, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 4601)Recruiting

Milan, 20133, Italy

Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 4604)Recruiting

Novara, 28100, Italy

Istituto Oncologico Veneto IRCCS ( Site 4603)Recruiting

Padova, 35128, Italy

Policlincio Gemelli ( Site 4602)Recruiting

Roma, 00168, Italy

Aichi Cancer Center ( Site 5117)Recruiting

Nagoya, Aichi-ken 464-8681, Japan

Nagoya City University Hospital ( Site 5108)Recruiting

Nagoya, Aichi-ken 467-8602, Japan

National Cancer Center Hospital East ( Site 5120)Recruiting

Kashiwa, Chiba 277-8577, Japan

National Hospital Organization Shikoku Cancer Center ( Site 5122)Recruiting

Matsuyama, Ehime 791-0280, Japan

Hokkaido University Hospital ( Site 5100)Recruiting

Sapporo, Hokkaido 060-8648, Japan

Kanazawa Medical University Hospital ( Site 5127)Recruiting

Kahoku-gun, Ishikawa-ken 920-0293, Japan

Study CoordinatorContact

+81-76-286-3511

Tokai University Hospital ( Site 5107)Recruiting

Isehara, Kanagawa 259-1193, Japan

St. Marianna University Hospital ( Site 5124)Recruiting

Kawasaki, Kanagawa 216-8511, Japan

Kitasato University Hospital ( Site 5123)Recruiting

Sagamihara, Kanagawa 252-0375, Japan

Kanagawa Cancer Center ( Site 5106)Recruiting

Yokohama, Kanagawa 241-8515, Japan

Mie University Hospital ( Site 5109)Recruiting

Tsu, Mie-ken 514-8507, Japan

Naha Nishi Clinic ( Site 5125)Recruiting

Naha, Okinawa 901-0154, Japan

The University of Osaka Hospital ( Site 5111)Recruiting

Suita, Osaka 565-0871, Japan

Saitama Medical University International Medical Center ( Site 5116)Recruiting

Hidaka, Saitama 350-1298, Japan

Juntendo University Hospital ( Site 5104)Recruiting

Bunkyo, Tokyo 113-8431, Japan

Study CoordinatorContact

+81-3-3813-3111

Cancer Institute Hospital of JFCR ( Site 5102)Recruiting

Koto, Tokyo 135-8550, Japan

Study CoordinatorContact

+81-3-3520-0111

Toranomon Hospital ( Site 5126)Recruiting

Minato, Tokyo 105-8470, Japan

Showa Medical University Hospital ( Site 5103)Recruiting

Shinagawa, Tokyo 142-8666, Japan

Study CoordinatorContact

+81-3-3784-8000

Tokyo Medical University Hospital ( Site 5121)Active, not recruiting

Shinjuku, Tokyo 160-0023, Japan

National Center for Global Health and Medicine ( Site 5105)Recruiting

Shinjuku, Tokyo 162-8655, Japan

Akita University Hospital ( Site 5115)Recruiting

Akita, 010-8543, Japan

National Hospital Organization Kyushu Cancer Center ( Site 5119)Recruiting

Fukuoka, 811-1395, Japan

Fukushima Medical University Hospital ( Site 5101)Recruiting

Fukushima, 960-1295, Japan

Hiroshima City Hiroshima Citizens Hospital ( Site 5113)Recruiting

Hiroshima, 730-8518, Japan

Social medical corporation Hakuaikai Sagara Hospital ( Site 5114)Recruiting

Kagoshima, 892-0833, Japan

Kyoto University Hospital ( Site 5110)Recruiting

Kyoto, 606-8507, Japan

Okayama University Hospital ( Site 5118)Recruiting

Okayama, 700-8558, Japan

Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 5112)Recruiting

Osaka, 541-8567, Japan

National Cancer Institute ( Site 5401)Recruiting

Putrajaya, Putrajaya 62250, Malaysia

Sarawak General Hospital ( Site 5400)Recruiting

Kuching, Sarawak 93586, Malaysia

Pantai Hospital Kuala Lumpur ( Site 5402)Recruiting

Kuala Lumpur, 59100, Malaysia

University Malaya Medical Centre ( Site 5403)Recruiting

Kuala Lumpur, 59100, Malaysia

CIO - Centro de Inmuno-Oncología de Occidente ( Site 2504)Recruiting

Guadalajara, Jalisco 44630, Mexico

Grupo Médico ASSET ( Site 2507)Recruiting

Mexico City, Mexico City 03100, Mexico

COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 2514)Recruiting

Mexico City, Mexico City 04700, Mexico

Centro Oncologico de Alta Especialidad, S.C. ( Site 2509)Recruiting

Mexico City, Mexico City 06140, Mexico

Higiea Oncologia ( Site 2505)Recruiting

Mexico City, Mexico City 11810, Mexico

Filios Alta Medicina ( Site 2506)Recruiting

Monterrey, Nuevo León 64460, Mexico

Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 2501)Recruiting

Monterrey, Nuevo León 64460, Mexico

Oncare - Unidad Valle ( Site 2502)Recruiting

San Pedro Garza García, Nuevo León 66220, Mexico

Centro de Investigacion Clinica de Oaxaca ( Site 2503)Recruiting

Oaxaca City, Oaxaca 68020, Mexico

Centro de Investigación Oncológica Galerías SC ( Site 2511)Recruiting

Aguascalientes, 20124, Mexico

Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 2510)Recruiting

Chihuahua City, 31123, Mexico

Centro Potosino de Investigación Médica ( Site 2512)Recruiting

San Luis Potosí City, 78250, Mexico

Ziekenhuis Rijnstate ( Site 4501)Recruiting

Arnhem, Gelderland 6815 AD, Netherlands

Zuyderland Medical Centre ( Site 4507)Recruiting

Sittard Geleen, Limburg 6162BP, Netherlands

Study CoordinatorContact

+31884590400

ETZ Elisabeth ( Site 4504)Recruiting

Tilburg, North Brabant 5022 GC, Netherlands

Deventer Ziekenhuis ( Site 4503)Recruiting

Deventer, Overijssel 7416 SE, Netherlands

Erasmus Medisch Centrum ( Site 4505)Recruiting

Rotterdam, South Holland 3015 GD, Netherlands

Meander Medisch Centrum ( Site 4500)Recruiting

Amersfoort, Utrecht 3813 TZ, Netherlands

Martini Ziekenhuis ( Site 4502)Recruiting

Groningen, 9728 NT, Netherlands

Harbour Cancer & Wellness ( Site 5600)Recruiting

Newmarket, Auckland 1023, New Zealand

Bowen Icon Cancer Centre ( Site 5601)Recruiting

Crofton Downs, Wellington Region 6035, New Zealand

Clínica Internacional - Sede San Borja ( Site 2604)Recruiting

Lima, 15036, Peru

IPOR Instituto Peruano de Oncología & Radioterapia ( Site 2601)Recruiting

Lima, 15036, Peru

Oncosalud ( Site 2600)Recruiting

Lima, 15036, Peru

Hospital Militar Central Coronel Luis Arias Schereiber ( Site 2603)Recruiting

Lima, 15076, Peru

Mary Mediatrix Medical Center ( Site 5702)Recruiting

Lipa, Batangas 4217, Philippines

Manila Doctors Hospital ( Site 5701)Recruiting

Manila, National Capital Region 1000, Philippines

THE MEDICAL CITY ILOILO ( Site 5704)Recruiting

Iloilo City, 5000, Philippines

Wielkopolskie Centrum Onkologii-Oddział Onkologii Klinicznej i Immunoonkologii z Pododdziałem Dzien ( Site 3811)Recruiting

Poznan, Greater Poland Voivodeship 61-866, Poland

Centrum Onkologii im prof Franciszka Lukaszczyka ( Site 3802)Recruiting

Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85-796, Poland

Pratia MCM Krakow ( Site 3812)Recruiting

Krakow, Lesser Poland Voivodeship 30-727, Poland

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3801)Completed

Siedlce, Masovian Voivodeship 08-110, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Piersi i Chirurgii ( Site 3803)Recruiting

Warsaw, Masovian Voivodeship 02-781, Poland

Mazowiecki Szpital Onkologiczny ( Site 3807)Recruiting

Wieliszew, Masovian Voivodeship 05-135, Poland

Bialostockie Centrum Onkologii ( Site 3810)Recruiting

Bialystok, Podlaskie Voivodeship 15-027, Poland

Szpitale Pomorskie Sp. z o. o. ( Site 3805)Recruiting

Gdynia, Pomeranian Voivodeship 81-519, Poland

Szpital Wojewodzki im.M.Kopernika. ( Site 3800)Recruiting

Koszalin, West Pomeranian Voivodeship 75-581, Poland

Institutul Oncologic Cluj ( Site 4701)Recruiting

Cluj-Napoca, Cluj 400015, Romania

S.C. Radiotherapy Center Cluj S.R.L ( Site 4705)Recruiting

Comuna Floresti, Cluj 407280, Romania

Study CoordinatorContact

+40219368

Centrul de Oncologie "Sfântul Nectarie" ( Site 4702)Recruiting

Craiova, Dolj 200542, Romania

Spitalul Municipal Schuller Ploiești ( Site 4707)Recruiting

Ploieşti, Prahova 100337, Romania

Cabinet Medical Oncomed ( Site 4704)Recruiting

Timișoara, Timiș County 300239, Romania

Spitalul Clinic Filantropia ( Site 4703)Recruiting

Bucharest, 011171, Romania

Centrul Medical Neolife- Baneasa ( Site 4706)Recruiting

Bucharest, 077190, Romania

National Cancer Center ( Site 5202)Recruiting

Goyang-si, Kyonggi-do 10408, South Korea

Seoul National University Bundang Hospital ( Site 5204)Recruiting

Seongnam, Kyonggi-do 13620, South Korea

Kyungpook National University Chilgok Hospital ( Site 5205)Recruiting

Daegu, Taegu-Kwangyokshi 41404, South Korea

Seoul National University Hospital ( Site 5200)Recruiting

Seoul, 03080, South Korea

Severance Hospital Yonsei University Health System ( Site 5201)Recruiting

Seoul, 03722, South Korea

Samsung Medical Center ( Site 5203)Recruiting

Seoul, 06351, South Korea

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 4104)Recruiting

Seville, Andalusia 41013, Spain

ICO L Hospitalet ( Site 4101)Recruiting

L'Hospitalet de Llobregat, Barcelona 08908, Spain

Hospital Clinico San Carlos ( Site 4100)Recruiting

Madrid, Madrid, Comunidad de 28040, Spain

Hospital General Universitario de Valencia ( Site 4102)Recruiting

Valencia, Valenciana, Comunitat 46014, Spain

Parc de Salut Mar - Hospital del Mar ( Site 4106)Recruiting

Barcelona, 08003, Spain

Hospital Beata María Ana ( Site 4105)Recruiting

Madrid, 28007, Spain

Hospital Universitario Ramon y Cajal ( Site 4103)Recruiting

Madrid, 28034, Spain

Taichung Veterans General Hospital ( Site 5303)Recruiting

Taichung, 407, Taiwan

National Cheng Kung University Hospital ( Site 5304)Recruiting

Tainan, 70403, Taiwan

National Taiwan University Hospital ( Site 5300)Recruiting

Taipei, 100225, Taiwan

Mackay Memorial Hospital ( Site 5301)Recruiting

Taipei, 104, Taiwan

Chang Gung Memorial Hospital ( Site 5302)Recruiting

Taoyuan, 333, Taiwan

Faculty of Medicine Siriraj Hospital ( Site 5800)Recruiting

Bangkoknoi, Bangkok 10700, Thailand

Study CoordinatorContact

+6624192938

Songklanagarind hospital ( Site 5801)Recruiting

Hat Yai, Changwat Songkhla 90110, Thailand

Faculty of Medicine - Khon Kaen University ( Site 5802)Recruiting

Khon Kaen, 40002, Thailand

Ege Universitesi Hastanesi ( Site 4803)Recruiting

Bornova, İzmir 35100, Turkey (Türkiye)

Adana Medical Park Seyhan Hastanesi ( Site 4804)Recruiting

Adana, 01140, Turkey (Türkiye)

Hacettepe Universite Hastaneleri ( Site 4800)Recruiting

Ankara, 06230, Turkey (Türkiye)

Gazi University Health Research and Application Center Gazi Hospital ( Site 4805)Recruiting

Ankara, 06560, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi ( Site 4801)Recruiting

Ankara, 06800, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 4802)Recruiting

Istanbul, 34722, Turkey (Türkiye)

Sakarya Egitim Arastirma Hsatanesi ( Site 4809)Recruiting

Sakarya, 54290, Turkey (Türkiye)

Samsun Medical Park Hastanesi ( Site 4810)Recruiting

Samsun, 55200, Turkey (Türkiye)

Royal Cornwall Hospital ( Site 4003)Recruiting

Truro, Cornwall TR13LJ, United Kingdom

St Bartholomew's Hospital ( Site 4001)Recruiting

London, London, City of EC1A7BE, United Kingdom

University College London Hospital ( Site 4007)Recruiting

London, London, City of NW1 2PG, United Kingdom

Nottingham University Hospital NHS Trust ( Site 4009)Recruiting

Nottingham, Nottinghamshire NG51PB, United Kingdom

Musgrove Park Hospital ( Site 4005)Recruiting

Taunton, Somerset TA1 5DA, United Kingdom

Queen Elizabeth Hospital Birmingham ( Site 4017)Recruiting

Birmingham, B15 2TH, United Kingdom

Velindre Cancer Centre Hospital ( Site 4008)Recruiting

Cardiff, CF142TL, United Kingdom

St. James s University Hospital ( Site 4004)Recruiting

Leeds, LS9 7TF, United Kingdom