Comparative Evaluation of Methylene Blue and Methylene Blue Nanoparticles Assisted Photodynamic Therapy As Adjunctive to Laser Treatment of Physiological Gingival Pigmentation: a Randomized Controlled Clinical Trial
Comparative Evaluation of Methylene Blue and Methylene Blue Nanoparticles Assisted Photodynamic Therapy As Adjunctive to Laser Treatment of Physiological Gingival Pigmentation: a Randomized Controlled Clinical Trial
This randomized controlled clinical trial aims to compare the effectiveness of methylene blue and methylene blue nanoparticles as adjuncts to photodynamic therapy in laser treatment of physiological gingival pigmentation. The study evaluates pigmentation reduction, recurrence rates, healing time, and patient satisfaction. Conducted at Kafrelsheikh University, it includes three patient groups: laser-only treatment, conventional methylene blue-assisted PDT with laser, and methylene blue nanoparticles-assisted PDT with laser. The findings will contribute to advancements in aesthetic dentistry and laser-assisted depigmentation techniques.
Inclusion Criteria:
Patients with physiological gingival pigmentation confirmed by clinical examination.
Age range: 18-50 years.
Patients with no history of systemic diseases or conditions that could affect wound healing (e.g., diabetes, autoimmune diseases).
Patients willing to undergo laser treatment and provide informed consent.
Non-smokers or individuals who have stopped smoking for at least six months.
Exclusion Criteria:
Patients with pathological gingival pigmentation (e.g., associated with syndromes or systemic conditions).
Use of medications affecting pigmentation or healing (e.g., anticoagulants, immunosuppressants).
Pregnant or lactating women or those taking contraceptive drugs.
Individuals with known allergies to methylene blue or nanoparticles.