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This work evaluated the systemic effect of different preoperative carbohydrate (CHO) loads in pediatrics undergoing elective surgery.
Children undergoing surgery experience stress due to disruptions in their daily routine and exposure to various perioperative circumstances that induce anxiety and pain.
The management of perioperative nutrition in pediatric patients is a crucial aspect of patient care.
The concept of preoperative carbohydrate (CHO) loading has gained attention as a potential strategy to mitigate these drawbacks. The administration of a CHO-rich drink two hours preoperative has been proposed to maintain euglycemia, decline IR, and enhance postoperative recovery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Apple juice group | Experimental | A preoperative carbohydrate load was done two hours before the operation using a10 ml/kg, with a maximal volume of 250 ml of commercial brand of apple juice (glucose 28 g in 250 ml). |
|
| Anhydrous glucose group | Experimental | A preoperative carbohydrate load was done using 1.75mg/kg/dose of anhydrous glucose (Alpha Chmika). |
|
| Water group | Other | Patients received water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Apple juice | Other | A preoperative carbohydrate load was done two hours before the operation using a10 ml/kg, with a maximal volume of 250 ml of commercial brand of apple juice (glucose 28 g in 250 ml). |
| Measure | Description | Time Frame |
|---|---|---|
| C-reactive protein (CRP) level | C-reactive protein (CRP) level was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. | 4 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Neutrophil/ lymphocyte ratio | Neutrophil/ lymphocyte ratio (NLR) was assessed 2 h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. | 4 hours postoperatively |
| Level of procalcitonin |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University | Tanta | El-Gharbia | 31527 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41357678 | Derived | Abdelwahed WMA, Abdelelsalam WM, Taha OA, Abdelbadie S, Taleb AMA. Effect of Preoperative 2-Hour Carbohydrate Load on Pediatric Patients Undergoing Elective Surgery: A Randomized Controlled Study. Anesthesiol Res Pract. 2025 Dec 3;2025:5580879. doi: 10.1155/anrp/5580879. eCollection 2025. |
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The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| ID | Term |
|---|---|
| D005947 | Glucose |
| D014867 | Water |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D006878 |
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| Anhydrous glucose | Drug | A preoperative carbohydrate load was done using 1.75mg/kg/dose of anhydrous glucose (Alpha Chmika). |
|
| Water | Other | Patients received water. |
|
Level of procalcitonin was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation.
| 4 hours postoperatively |
| Homeostatic model assessment for insulin resistance | Homeostatic model assessment for insulin resistance(HOMA.IR) was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. | 4 hours postoperatively |
| Level of C-peptide | Level of C-peptide was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. | 4 hours postoperatively |
| Level of random blood glucose | Level of random blood glucose (RBG) was measured at two hours before the surgery. | Two hours before the surgery |
| Patient's parent's satisfaction | Parent satisfaction level was evaluated by 3-point Likert scale (1, unsatisfied; 2, neutral; 3, satisfied). | 4 hours postoperatively |
| Incidence of complications | Incidence of complications such as perioperative nausea, vomiting, and aspiration were documented. | 4 hours postoperatively |
| Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |