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The goal of this clinical trial is to learn if garlic tablets works to prevent nosocomial infections in hospitalized patients in ICU. The main questions it aims to answer are:
Does garlic tablets administration lower the occurence of nosocomial infections in hospitalized patients in ICU?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The intervention group | Experimental | The patients in the intervention group which will receive garlic tablets (Tomex plus 300 mg) two tablets twice daily for 6 days just after ICU admission |
|
| The control group | No Intervention | The patients in the control group which will not receive the garlic tablets. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Garlic powder standardized to allicin | Drug | The intervention is the administration of garlic tablets (Tomex plus 300 mg) two tablets twice daily (which contains 5.4 mg allicin the active ingredient with anibacterial effect) for 6 days just after ICU admission |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of central line-associated bloodstream infections, catheter- associated urinary tract infections, surgical site infections and ventilator- associated pneumonia in the two groups (by cultures results). | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Values of Blood white cell count, body temperature and C-reactive protein of the patient in the two groups . | The Mean of Blood white cell count (number per micro liter) , body temperature ( by the degree Celsius) and C-reactive protein (milligrams per liter ) of the patients in the two groups will be calculated. | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Antibiotics consumption as total number of vials per each antibiotic in the two groups. | one year | |
| Lenghth of stay of patients in ICU (by average number of days) in the two groups | one year | |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alexandria Main University Hospital | Alexandria | Alexandria Governorate | 21563 | Egypt |
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| ID | Term |
|---|---|
| D003428 | Cross Infection |
| ID | Term |
|---|---|
| D007239 | Infections |
| D007049 | Iatrogenic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
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It is a randomized non blinded controlled trial. Eligible patients will be randomly divided into two groups: An intervention group which will receive garlic tablets (Tomex plus 300 mg) two tablets twice daily for 6 days just after ICU admission and a control group which will not receive the garlic tablets.
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| Values of Blood white cell count, body temperature and C-reactive protein of the patient in the two groups . |
The Mean of Blood white cell count, body temperature and C-reactive protein of the patient in the two groups will be calculated. |
| one year |
| Mortality rate of patients in the two groups |
| one year |
| D013568 |
| Pathological Conditions, Signs and Symptoms |