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The goal of this observational study is to learn about the brain imaging changes associated with concussion using a very detailed (7T) MRI scanner.
To do this, the investigators will study 7T MRI brain imaging in patients aged 18-40 who present to the Emergency Department within 96 hours of a head injury. Patients will be eligible if they have had a normal CT brain as part of their usual care.
The investigators will compare brain imaging from patients who have completely recovered from an episode of concussion to patients who still have significant symptoms at approximately 28 days after a head injury.
The study attempts to answer the following questions:
Evaluation of symptoms will be conducted at presentation in the Emergency Department and at 25 +/- 3 days after head injury. This will be assessed using 2 validated questionnaires: the Neurological Assessment Questionnaire (NAQ) and the Post Concussion Symptom Scale (PCSS).
Lifetime incidence of concussion will be assessed at 7T MRI using the a modified version of the Brain Injury Screening Questionnaire (BISQ).
Information will also be collected regarding painkiller use, anticoagulation, return to work, and any related further unscheduled care admissions or CT head imaging.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients who have completely recovered from concussion | Recovery from concussion will be assessed at 25 +/- 3 days using a validated symptom score, the Post Concussion Symptom Scale (PCSS). This group will have a PCSS = 0. |
| |
| Patients who have ongoing symptoms from concussion | Recovery from concussion will be assessed at 25 +/- 3 days using a validated symptom score, the Post Concussion Symptom Scale (PCSS). This group will have a PCSS > 10. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 7T MRI brain | Diagnostic Test | A very detailed MRI scan of the brain using a 7T MRI scanner. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Microvascular Pathology (Blood Vessel Changes) on 7T MRI brain | To explore whether patients with ongoing symptoms after a concussion show greater 7T MRI brain imaging evidence of microvascular pathology (blood vessel changes) at 28 (± 14) days after their injury in comparison to patients who have recovered fully. | 28 +/- 14 days from head injury |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Brain Signalling Pathways on 7T MRI | To explore whether patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of ongoing metabolic disturbance in brain signalling pathways at 28 (± 14) days after their injury, in comparison to patients who have recovered fully. | At 28 +/- 14 days from head injury |
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Inclusion Criteria:
Exclusion Criteria:
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Patients will be recruited from the Emergency Department at the Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Prof Stewart | Contact | (0141) 354 9535 | william.stewart@glasgow.ac.uk | |
| Prof Lowe | Contact | (0141) 452 2932 | david.lowe@glasgow.ac.uk |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D001924 | Brain Concussion |
| D006259 | Craniocerebral Trauma |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D020196 |
| Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D016489 | Head Injuries, Closed |
| D014949 | Wounds, Nonpenetrating |