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Mild Cognitive Impairment (MCI) in older adults is linked to muscle loss (sarcopenia) and can lead to dementia, with pain further impacting cognitive and physical performance. Tai Chi, a mind-body exercise, is recommended for managing MCI as it supports cognitive function, mood, and physical health.
The investigators' first goal is to characterize the correlation of heart rate variability and cortical activity on cognitive function and the psychosocial correlates of pain interference and social isolation on cognitive function at baseline and post-intervention (8 weeks of Tai Chi). The second goal is to explain the role of sarcopenia and obesity in the relationship between pain interference and cognitive function. The investigators also want to examine the index of the predictive capacity regarding sarcopenia and obesity on cognitive function outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai Chi | Experimental | The Tai Chi program content is based on the Harvard Medical School (HMS) Guide to Tai Chi, developed by clinical scientist Dr. Peter M. Wayne. Each participant will receive a workbook that describes the philosophy, evidence, and practice of Tai Chi, along with a video series for home practice that features the exercises from the HMS Guide to Tai Chi program. The in-person classes will be led by the Principal Investigator (PI) and delivered weekly over 8 weeks, with 75-minute sessions. The in-person and video series will introduce practice principles and tips on establishing and maintaining a practice, followed by a series of warm-up exercises, Tai Chi movements, and cool-down exercises. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tai Chi | Behavioral | The Tai Chi program content is based on the Harvard Medical School (HMS) Guide to Tai Chi, developed by clinical scientist Dr. Peter M. Wayne. Each participant will receive a workbook that describes the philosophy, evidence, and practice of Tai Chi, along with a video series for home practice that features the exercises from the HMS Guide to Tai Chi program. The in-person classes will be led by the PI and delivered weekly over 8 weeks, with 75-minute sessions. The in-person and video series will include an introduction to the principles of practice and tips on establishing and maintaining a practice, followed by a series of warm-up exercises, Tai Chi movements, and cool-down exercises. The Tin-person (and offer virtual live sessions for those who cannot attend in-person) over 8 weeks, accompanied by a workbook and video-recorded practices to promote self-management. |
| Measure | Description | Time Frame |
|---|---|---|
| Executive Function - Stroop Color-Word Interference Test | Delis-Kaplan Executive Function System Stroop Color-Word Interference Test | From enrollment to the end of treatment at 8 weeks |
| Executive Function - Semantic Fluency Test | Repeatable Battery for the Assessment of Neuropsychological Status - Semantic Fluency Test | From enrollment to the end of treatment at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive Function - Processing Speed | Repeatable Battery for the Assessment of Neuropsychological Status Coding Test | From enrollment to the end of treatment at 8 weeks |
| Pain Interference | Patient Reported Outcome Measurement Information System (PROMIS) - Pain Interference Item Bank |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive Assessment Screen | Montreal Cognitive Assessment used as a screening tool which measures short term memory, visuospatial abilities, executive functions, attention, concentration and working memory, and language orientation to time and place. | From enrollment only |
| Body Mass Index |
Inclusion Criteria:
Exclusion Criteria:
2. Currently or recently practicing Tai Chi. Participants will be excluded if they are currently practicing Tai Chi. If participants have previously engaged in Tai Chi, there will be a washout period of at least 6 months before considering enrollment in the study.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nicholas Karayannis, MPT, PhD | Contact | +1 740-593-1044 | nvkaray@ohio.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio University | Recruiting | Athens | Ohio | 45701 | United States |
There is a plan to make individual participant data (IPD) collected in this study, including data dictionaries, available to other researchers after the end of the study after de-identification.
Immediately following publication. No end date.
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|
| From enrollment to the end of treatment at 8 weeks |
| Social Isolation | Patient Reported Outcome Measurement Information System (PROMIS) Social Isolation Item Bank | From enrollment to the end of treatment at 8 weeks |
| Positive Affect | Patient Reported Outcome Measurement Information System (PROMIS) Positive Affect Item Bank | From enrollment to the end of treatment at 8 weeks |
| Meaning and Purpose | Patient Reported Outcome Measurement Information System (PROMIS) Meaning and Purpose Item bank | From enrollment to the end of treatment at 8 weeks |
| Heart Rate Variability | Heart Rate Variability recorded while sitting for 5 minutes using a photoplethysmogram. | From enrollment to the end of treatment at 8 weeks |
| Cortical activity | Cortical activity will be recorded during a brief Tai Chi Practice before and after the 8-week Tai Chi intervention using a functional Near Infrared Spectroscopy system. | From enrollment to the end of treatment at 8 weeks |
Body Mass Index (BMI) will be assessed to identify the moderating role of obesity on pain interference and executive function. Weight and height will be combined to report BMI in kg/m^2). |
| From enrollment only |
| Physical Performance Test Battery for Sarcopenia (1 of 6) | (1) Hand Grip Strength using a JAMARĀ® dynamometer, adjusted to fit participants' hands as described elsewhere. A minimum of three trials with 60 seconds of rest between trials, and additional trials if the highest two values differ by more than 3 kg. Unit: Force in kilograms The investigators will diagnose sarcopenia using the European Working Group's (EWGSOP2) revised consensus definition, which involves assessing two measures and current sarcopenia reference values: (i) hand grip strength via dynamometry and (ii) gait speed. | From enrollment to the end of treatment at 8 weeks |
| Physical Performance Test Battery for Sarcopenia (2 of 6) | (2) Usual Gait Speed over 4 meters to assess for gait speed. Unit: Seconds The investigators will diagnose sarcopenia using the European Working Group's (EWGSOP2) revised consensus definition, which involves assessing two measures and current sarcopenia reference values: (i) hand grip strength via dynamometry and (ii) gait speed. | From enrollment to the end of treatment at 8 weeks |
| Physical Performance Test Battery for Sarcopenia (3 of 6) | (3) Six Minute Walk Test to assess for submaximal aerobic walking capacity. Unit: Meters | From enrollment to the end of treatment at 8 weeks |
| Physical Performance Test Battery for Sarcopenia (4 of 6) | (4) Four-Square Step Test to assess for dynamic balance that involves stepping over objects forward, sideways, and backward. Unit: Seconds | From enrollment to the end of treatment at 8 weeks |
| Physical Performance Test Battery for Sarcopenia (5 of 6) | (5) 5x Repeated Sit-to-Stand Test to assess lower extremity strength. Unit: Seconds | From enrollment to the end of treatment at 8 weeks |
| Physical Performance Test Battery for Sarcopenia (6 of 6) | (6) Stair Climb Power Test to assess lower extremity power. Unit: Seconds. | From enrollment to the end of treatment at 8 weeks |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D026302 | Tai Ji |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026241 | Exercise Movement Techniques |
| D026741 | Physical Therapy Modalities |
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