161Tb-NYM032 is a radiopharmaceutical labeled with a PSMA ligand, used for the treatment of metastatic castration-resistant prostate cancer, which is needed for clinical trial to be conducted.

**1. Inclusion Criteria**

1. The participant voluntarily signs the informed consent form and is able to complete the trial according to the protocol requirements.

2. Male, aged 18 years or older.

3. Diagnosed with metastatic castration-resistant prostate cancer (mCRPC) as per PCWG3 criteria.

4. Positive results on 68Ga-NYM032 positron emission tomography (PET)/computed tomography (CT) scan.

5. Must have received at least one NAAD treatment (e.g., enzalutamide and/or abiraterone) or at least one taxane-based treatment regimen, or be intolerant to or refuse taxane therapy for metastatic castration-resistant prostate cancer.

6. ECOG performance status of 0-2.

7. Expected survival of ≥6 months.

8. Laboratory parameters must meet the following:

   1. ALT and AST must not exceed 3 times the upper limit of normal (ULN); BUN and Cr must not exceed 1.5 times the ULN.
   2. Blood counts: WBC ≥3.5×10^9/L, PLT ≥100×10^9/L, Hb ≥90 g/L.